Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 8, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Bilirubin of 1.7 in an 18-year-old Male with Fatigue and Underweight

Single Most Likely Diagnosis

  • Gilbert Syndrome: A benign condition characterized by mildly elevated levels of unconjugated bilirubin, often presenting with fatigue and sometimes weight loss. The bilirubin level of 1.7 is within the range typically seen in Gilbert Syndrome, and it's a common condition in young adults.

Other Likely Diagnoses

  • Viral Hepatitis: Although the bilirubin level is not markedly elevated, viral hepatitis (such as hepatitis A, B, or C) can present with fatigue, weight loss, and mildly elevated bilirubin levels. The underweight status and fatigue could be indicative of a chronic infection.
  • Hemolytic Anemia: Conditions like autoimmune hemolytic anemia could lead to elevated bilirubin due to increased red blood cell breakdown. Fatigue is a common symptom due to anemia, and weight loss can occur if the condition is severe or chronic.
  • Malnutrition: Poor dietary intake can lead to a range of deficiencies, including those that affect liver function or increase the risk of infections, potentially resulting in elevated bilirubin levels. The underweight status suggests malnutrition could be a contributing factor.

Do Not Miss Diagnoses

  • Hepatocellular Carcinoma: Although rare in young adults, any liver dysfunction warrants consideration of serious underlying conditions. Early detection is crucial for treatment outcomes.
  • Wilson's Disease: An inherited disorder that leads to copper accumulation in the liver, potentially causing liver dysfunction. It's essential to consider this diagnosis due to its severe consequences if left untreated.
  • Leptospirosis: A bacterial infection that can cause liver and kidney dysfunction, presenting with a range of symptoms including fatigue and weight loss. It's crucial to diagnose promptly due to the potential for severe outcomes.

Rare Diagnoses

  • Dubin-Johnson Syndrome: A rare genetic disorder characterized by chronic jaundice due to an inability to secrete conjugated bilirubin into the bile. It's less likely but should be considered in the differential diagnosis of elevated bilirubin.
  • Crigler-Najjar Syndrome: A rare condition causing severely elevated levels of unconjugated bilirubin. Although the bilirubin level in this case is not extremely high, it's a consideration in the differential diagnosis, especially if other causes are ruled out.
  • Primary Biliary Cholangitis (PBC): An autoimmune disease of the liver that can lead to cirrhosis. It's more common in women but should be considered in any patient with unexplained liver dysfunction.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.