What are the differential diagnoses of perioral dermatitis?

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Last updated: February 9, 2025View editorial policy

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Differential Diagnosis for Perioral Dermatitis

  • Single Most Likely Diagnosis
    • Rosacea: This is the most likely diagnosis due to the similar presentation of perioral dermatitis, which includes papules, pustules, and erythema around the mouth. Rosacea is a common condition that can be easily mistaken for perioral dermatitis.
  • Other Likely Diagnoses
    • Acne vulgaris: Acne can present with similar lesions around the mouth and can be difficult to distinguish from perioral dermatitis.
    • Contact dermatitis: Irritant or allergic contact dermatitis can cause a rash around the mouth, especially if the patient is using a new skincare product or makeup.
    • Seborrheic dermatitis: This condition can cause a red, itchy rash on the face, including around the mouth.
  • Do Not Miss Diagnoses
    • Lupus miliaris disseminatus faciei (LMDF): Although rare, LMDF is a granulomatous condition that can present with perioral lesions and can be mistaken for perioral dermatitis. Missing this diagnosis can lead to delayed treatment and potential scarring.
    • Sarcoidosis: Sarcoidosis is a systemic disease that can cause skin lesions, including perioral lesions. Missing this diagnosis can lead to delayed treatment of a potentially serious condition.
  • Rare Diagnoses
    • Granulomatous perioral dermatitis: A rare variant of perioral dermatitis characterized by granulomatous lesions.
    • Melkersson-Rosenthal syndrome: A rare neurocutaneous disorder that can cause perioral lesions, facial paralysis, and other symptoms.
    • Perioral dermatitis-like lesions in immunosuppressed patients: Certain infections, such as histoplasmosis or cryptococcosis, can cause perioral lesions in immunosuppressed patients.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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