When can a child with impetigo return to daycare after starting antibiotic treatment?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 9, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

When Can a Child with Impetigo Return to Daycare After Starting Antibiotic Treatment?

A child with impetigo should not return to daycare until 24 hours after starting effective antibiotic treatment, as the condition is highly contagious until that point.

Understanding Impetigo

Impetigo is a highly contagious, superficial bacterial skin infection characterized by:

  • Honey-colored crusts (nonbullous impetigo, 70% of cases)
  • Vesicles that rupture and form crusts on face, arms, and trunk
  • Possible large, flaccid bullae (bullous impetigo, 30% of cases)

The infection is most commonly caused by:

  • Staphylococcus aureus
  • Streptococcus pyogenes (Group A Streptococcus)

Contagiousness and Daycare Return Guidelines

The child described in the question has classic signs of impetigo, which is definitely contagious. According to infection control guidelines:

  • Patients with Group A Streptococcal infections (including impetigo) should be isolated for a minimum of 24 hours after starting effective antibiotic therapy 1
  • After 24 hours of appropriate antibiotic treatment, the risk of transmission decreases significantly

Treatment Options

Topical Antibiotics (First-line for limited lesions)

  • Mupirocin 2% ointment applied three times daily for 5-7 days 1, 2
  • Retapamulin or fusidic acid as alternatives 2
  • Clinical improvement typically seen within 3-5 days 3

Oral Antibiotics (For extensive disease)

  • Clindamycin
  • Cephalexin
  • Amoxicillin/clavulanate
  • Dicloxacillin
  • Macrolides (with caution due to increasing resistance)

Note: Penicillin V is not recommended as it is seldom effective for impetigo 4, 5

Key Points for Parents

When counseling the mother about her child's return to daycare:

  1. Explain that impetigo is highly contagious and spreads through:

    • Direct contact with lesions
    • Contact with items touched by infected person
  2. Advise that the child should:

    • Complete the full course of prescribed antibiotics
    • Stay home from daycare for at least 24 hours after starting antibiotics
    • Return only after 24 hours of treatment, even if lesions are still present
  3. Recommend good hygiene practices:

    • Regular handwashing
    • Avoiding sharing personal items
    • Keeping nails short and clean
    • Covering lesions if possible when returning to daycare

Common Pitfalls to Avoid

  • Do not wait until lesions are completely healed before allowing return to daycare - this is unnecessary if appropriate antibiotic treatment has been given for 24 hours
  • Do not use topical disinfectants as they are inferior to antibiotics and should not be used 2, 5
  • Do not use penicillin V as it has been shown to be less effective than other antibiotics for impetigo 4, 5

The child can safely return to daycare after 24 hours of effective antibiotic treatment, even though the lesions may still be present.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Impetigo: diagnosis and treatment.

American family physician, 2014

Research

Mupirocin: a new topical therapy for impetigo.

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners, 1989

Research

Diagnosis and treatment of impetigo.

American family physician, 2007

Research

Interventions for impetigo.

The Cochrane database of systematic reviews, 2012

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.