What is the treatment for a wasp sting?

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Last updated: September 9, 2025View editorial policy

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Treatment for Wasp Stings

For wasp stings, remove the stinger quickly if present, clean the area with soap and water, apply ice to reduce swelling, and use over-the-counter pain medications and antihistamines for symptom relief; however, for systemic reactions or anaphylaxis, immediately administer intramuscular epinephrine as the first-line treatment. 1

Initial Assessment and Treatment

Local Reactions (Most Common)

  1. Remove stinger (if present) as quickly as possible - the method is less important than speed 1
  2. Clean the wound thoroughly with soap and water 1
  3. Apply ice or cold packs to the sting site with a thin barrier between ice and skin to reduce pain and swelling 1
  4. Symptom management:
    • Over-the-counter pain medications (acetaminophen or NSAIDs like ibuprofen)
    • Oral antihistamines for itching
    • Topical corticosteroids for inflammation 1

Systemic Reactions and Anaphylaxis (Emergency)

  1. Administer epinephrine immediately via intramuscular injection into the anterolateral thigh:
    • Adults: 0.3-0.5 mg
    • Children: 0.01 mg/kg up to 0.3 mg 1, 2
  2. Secondary treatments (should never delay epinephrine):
    • H1 antihistamines
    • H2 antihistamines
    • Corticosteroids 1
  3. Monitor patient for at least 4-6 hours after treatment for signs of delayed or biphasic reactions 1

Special Considerations

Large Local Reactions

  • May affect up to 25% of the population 3
  • Oral antihistamines and oral corticosteroids may help manage symptoms 1
  • Generally have a low risk of progressing to systemic reactions 1

Risk Factors for Severe Reactions

  • History of previous systemic reactions
  • Underlying mastocytosis (found in 3-5% of patients with sting anaphylaxis) 3
  • Cardiovascular disease (still should receive epinephrine as benefits outweigh risks) 1

Potential Complications

  • Infection at sting sites 1, 2
  • Rarely, serious conditions like:
    • Rhabdomyolysis (muscle breakdown) 4
    • Allergic encephalitis 5

Prevention and Follow-up Care

Prevention Strategies

  • Have known nests removed by professionals
  • Avoid wearing bright colors or flowery prints
  • Wear protective clothing (long pants, long sleeves, closed shoes) 1

Follow-up Recommendations

  • Patients with history of systemic reactions should:
    • Carry autoinjectable epinephrine
    • Be educated on proper use and indications
    • Be referred to an allergist-immunologist 1
  • Consider venom immunotherapy (VIT) for patients with history of systemic reactions and specific IgE to venom allergens 1

Infection Prevention

  • Consider preemptive antibiotic therapy (3-5 days) for patients who are:
    • Immunocompromised
    • Asplenic
    • Have advanced liver disease
    • Have moderate to severe injuries, especially to hand or face 1
  • Update tetanus prophylaxis if vaccination is not current (within 10 years) 1

Common Pitfalls to Avoid

  • Delaying epinephrine administration in anaphylaxis (most critical error)
  • Failing to monitor patients after treatment (biphasic reactions can occur)
  • Underestimating the potential severity of wasp stings (can be fatal in sensitive individuals)
  • Not referring patients with systemic reactions to an allergist for long-term management

References

Guideline

Anaphylaxis Treatment Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Insect stings: clinical features and management.

Deutsches Arzteblatt international, 2012

Research

Rhabdomyolysis due to Multiple Wasp Stings.

Case reports in dermatological medicine, 2012

Research

Wasp sting-related allergic encephalitis.

Practical neurology, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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