What is the best imaging modality for assessing and managing pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 14, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

For pain evaluation, the best imaging approach depends on the suspected cause and location of pain, with MRI being the preferred modality for assessing and managing pain, especially for soft tissue assessment and evaluating joint pain, spinal conditions, and nerve compression, as recommended by the American College of Physicians and the American Pain Society 1.

Key Considerations for Imaging Modalities

  • X-rays are typically the first-line imaging choice for musculoskeletal pain, as they are readily available, inexpensive, and good for detecting fractures, dislocations, and degenerative changes.
  • MRI is superior for soft tissue assessment, making it ideal for evaluating joint pain, spinal conditions, and nerve compression.
  • CT scans are excellent for detailed bone imaging and are particularly useful for complex fractures or when MRI is contraindicated.
  • Ultrasound offers real-time imaging for joint effusions, tendon injuries, and can guide interventional procedures.
  • For abdominal or pelvic pain, CT is often preferred for its comprehensive evaluation of organs, while ultrasound may be used initially, especially in younger patients or pregnant women to avoid radiation.

Recommendations for Specific Pain Conditions

  • For low back pain, prompt work-up with MRI or CT is recommended in patients who have severe or progressive neurologic deficits or are suspected of having a serious underlying condition, with MRI being generally preferred over CT if available 1.
  • For chronic foot pain, radiography is recommended as the initial imaging study, with MRI or CT being considered for further evaluation if necessary 1.
  • For chronic hip pain, radiographs are a good first step to screen hip pain, with MRI or CT being considered for further evaluation if necessary 1.

Importance of Clinical Presentation and Radiation Exposure

  • The selection of imaging modality should be guided by the clinical presentation, suspected pathology, and consideration of radiation exposure, with the least invasive and most appropriate test chosen first.
  • It is essential to avoid overuse of imaging, surgery, and opioids, and to provide education and advice to patients with musculoskeletal pain conditions, as recommended by high-quality clinical practice guidelines 1.

From the Research

Imaging Modalities for Assessing and Managing Pain

The choice of imaging modality for assessing and managing pain depends on various factors, including the type of pain, suspected underlying cause, and individual patient characteristics. Some studies suggest the following:

  • Musculoskeletal imaging includes radiographs, computed tomography scans, bone scans, magnetic resonance imaging (MRI), and musculoskeletal ultrasonography, each with its advantages and disadvantages 2.
  • A detailed history and physical examination are crucial for localizing the pain generator and choosing the most appropriate imaging studies, based on the suspected injured tissue 3.
  • For chronic myofascial pain syndrome (MPS), MRI remains the standard method of imaging skeletal muscle, and techniques such as diffusion tensor imaging (DTI) can quantify muscle injury, strain, and structure 4.

Specific Imaging Modalities for Pain Assessment

Different imaging modalities may be suitable for specific types of pain:

  • For right upper quadrant pain, an imaging approach based on identifying clinical signs and symptoms can aid in choosing the appropriate modality, such as sonography, biliary scintigraphy, CT, or MR 5.
  • Neuroimaging methods, including functional MRI and other techniques, can provide a non-invasive, systems-level understanding of the central mechanisms involved in pain processing and may aid in diagnosing and treating chronic pain 6.

Considerations for Imaging Modality Selection

When selecting an imaging modality for pain assessment and management:

  • It is essential to consider the potential advantages and disadvantages of each modality, as well as the individual patient's characteristics and suspected underlying cause of pain 2, 3.
  • A thorough history and physical examination are necessary to guide the choice of imaging modality and ensure that imaging is used judiciously to avoid unnecessary radiation exposure, minimize cost, and avoid therapy targeting asymptomatic imaging abnormalities 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Musculoskeletal imaging: types and indications.

The Medical clinics of North America, 2014

Research

Imaging the patient with right upper quadrant pain.

Seminars in roentgenology, 2001

Research

Imaging pain.

British journal of anaesthesia, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.