Reference Range for DHEA Sulfate in a 35-Year-Old Male
The normal reference range for DHEA sulfate in a 35-year-old male is approximately 160-450 μg/dL (1.6-4.5 μg/mL).
Age-Specific Reference Ranges
DHEA sulfate (DHEAS) is an adrenal androgen that follows a predictable pattern throughout the lifespan. Levels peak in early adulthood and then gradually decline with age. For men in their 30s, reference ranges are particularly important as they are typically near their peak values.
Key considerations for DHEAS reference ranges:
- DHEAS levels show significant age-related variation
- Morning measurements are preferred due to diurnal variation 1
- Different assay methods may yield slightly different reference ranges 2
- Ethnicity may influence normal ranges in some populations
Clinical Significance of DHEAS Levels
DHEAS serves as:
- An important marker of adrenal function
- A precursor to testosterone and other sex hormones
- A potential indicator of overall health status
Low DHEAS Levels
Low DHEAS levels in a 35-year-old male (<160 μg/dL) may indicate:
- Adrenal insufficiency
- Pituitary dysfunction
- Chronic illness
- Certain medications (especially glucocorticoids)
Morning cortisol levels should be checked if adrenal insufficiency is suspected, as this can present with fatigue and decreased libido 1.
Elevated DHEAS Levels
Elevated DHEAS levels (>450 μg/dL) may suggest:
- Adrenal hyperplasia
- Adrenal tumors
- Polycystic ovary syndrome (in women)
- Certain medications
Age-Related Decline
Research shows that DHEAS levels decline approximately 2% per year after age 30 3. By age 70-80, DHEAS concentrations are typically only 10-20% of those in young adults 3. This decline has been termed "adrenopause" and has prompted interest in DHEAS replacement therapy in older adults.
Measurement Considerations
When measuring DHEAS:
- Use consistent laboratory methods for longitudinal monitoring
- Consider measuring both total and free testosterone alongside DHEAS
- Interpret results in the context of clinical symptoms 1
- Morning samples provide the most reliable results
Common Pitfalls
- Using inappropriate age-specific reference ranges
- Failing to consider diurnal variation
- Not accounting for assay-specific differences in reference ranges
- Overlooking non-hormonal causes of symptoms
- Relying solely on a single measurement without clinical correlation
For accurate clinical assessment, DHEAS levels should be interpreted alongside other hormonal parameters and clinical symptoms, particularly when evaluating potential hypogonadism or adrenal dysfunction.