What is the effect of Monosodium Glutamate (MSG)?

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Last updated: March 14, 2025View editorial policy

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From the Research

Monosodium glutamate (MSG) can have adverse health effects, particularly with high doses and repeated exposure, and its consumption should be limited to minimize the risk of embryotoxicity, teratogenicity, obesity, cardiotoxicity, hepatotoxicity, kidney toxicity, neurotoxicity, endothelial dysfunction, reproductive toxicities, alteration of lipid, and glucose metabolism 1.

Key Findings

  • High doses and repeated exposure to MSG have been associated with various health problems, including obesity, cardiotoxicity, and neurotoxicity 1, 2.
  • MSG can also affect lipid and glucose metabolism, leading to an increased risk of metabolic disorders 1, 3.
  • Some natural products, such as Calendula officinalis, Curcuma longa, and Green Tea, may have protective effects against MSG-induced toxicity 4.

Recommendations

  • Limit MSG consumption to minimize the risk of adverse health effects, particularly for individuals who are sensitive to MSG or have pre-existing health conditions 1, 2.
  • Consider alternative flavor enhancers, such as herbs and spices, to reduce MSG intake 1.
  • Further research is needed to fully understand the effects of MSG on human health and to establish safe consumption levels 2, 3.

Important Considerations

  • MSG is widely used in food products, and its consumption can be difficult to avoid entirely 1, 2.
  • Individuals who are concerned about MSG sensitivity or adverse health effects should consult with a healthcare professional for personalized advice 1, 2.
  • More research is needed to understand the potential benefits and risks of MSG consumption, particularly in relation to obesity and metabolic disorders 3, 5.

References

Research

Reconsideration of the health effects of monosodium glutamate: from bench to bedside evidence.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2025

Research

A review of the alleged health hazards of monosodium glutamate.

Comprehensive reviews in food science and food safety, 2019

Research

Monosodium glutamate: A hidden risk factor for obesity?

Obesity reviews : an official journal of the International Association for the Study of Obesity, 2025

Research

Natural products as safeguards against monosodium glutamate-induced toxicity.

Iranian journal of basic medical sciences, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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