What are the effects of Siraitia grosvenorii (Monk fruit)?

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Last updated: March 14, 2025View editorial policy

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From the Guidelines

Monk fruit, derived from the Siraitia grosvenorii plant, is a safe and effective zero-calorie sweetener alternative to sugar, ideal for managing diabetes, ketogenic diets, or reducing calorie intake, as supported by the FDA's GRAS designation 1.

Key Points

  • Monk fruit sweetener is 100-250 times sweeter than sucrose, making it a suitable option for those who want to reduce their sugar intake.
  • The sweetness comes from compounds called mogrosides, particularly mogroside V, which do not affect blood sugar levels.
  • Monk fruit sweetener can be used in cooking, baking, and beverages, but due to its intense sweetness, less of it is needed compared to sugar.
  • When purchasing monk fruit products, it is recommended to look for pure versions without added dextrose or erythritol to avoid other sweeteners.
  • Some people may detect a slight aftertaste, but many find it more pleasant than artificial sweeteners.
  • Monk fruit also contains antioxidants and has been used in traditional Chinese medicine for its potential anti-inflammatory properties.

Recommendations

  • For individuals with diabetes or those trying to manage their blood sugar levels, monk fruit sweetener can be a useful alternative to sugar.
  • When using monk fruit sweetener, it is essential to follow the recommended dosage and start with a small amount to adjust to its intense sweetness.
  • Monk fruit sweetener can be used in conjunction with other dietary changes, such as reducing carbohydrate intake or increasing physical activity, to help manage diabetes or promote weight loss.
  • As with any new food or supplement, it is recommended to consult with a healthcare professional before using monk fruit sweetener, especially for individuals with underlying health conditions or taking medications.

From the Research

Effects of Siraitia grosvenorii (Monk Fruit)

  • The effects of Siraitia grosvenorii, also known as monk fruit, have been studied in various contexts, including its potential as a natural sweetener and its impact on health outcomes 2, 3.
  • Research has shown that monk fruit extract can improve serum lipid levels, respiratory exchange rate, and heat level in type 2 diabetic rats, and may affect the expression of genes involved in binding, catalytic activity, and transporter activity 4.
  • Monk fruit has also been found to have immunomodulatory effects, including enhancing various immune factors and impacting the diversity and gut microbiota composition in mice 5.
  • A study on the effects of non-nutritive sweeteners, including monk fruit, on 24-h glucose profiles found no significant differences in mean 24-h glucose, incremental area under the curve, and total area under the curve for glucose, and 24-h glycaemic variability between monk fruit and other sweeteners 6.
  • The potential health benefits of monk fruit include:
    • Weight management
    • Improved immunity
    • Gut microbiota modulatory effects
    • Improved serum lipid levels
    • Activation of AMPK signaling pathway
  • Overall, the available evidence suggests that monk fruit may be a useful alternative to traditional sweeteners, with potential health benefits and minimal effects on glucose profiles 2, 3, 4, 5, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Sugar or Sweetener?

Southern medical journal, 2024

Research

In search for an alternative to sugar to reduce obesity.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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