Ozempic (Semaglutide) and Maviret (Glecaprevir/Pibrentasvir) Can Be Safely Used Together
Yes, it is safe to use Ozempic (semaglutide) and Maviret (glecaprevir/pibrentasvir) together as there are no significant drug interactions between these medications that would require dose adjustments or contraindicate their concurrent use.
Evidence for Safety of Combined Use
The FDA drug label for Maviret (glecaprevir/pibrentasvir) does not list any interactions with GLP-1 receptor agonists like semaglutide 1. According to hepatology guidelines, the main drug interaction concerns with Maviret involve:
- P-glycoprotein (P-gp) substrates
- Breast cancer resistance protein (BCRP) substrates
- OATP1B1/3 substrates
- Drugs that strongly induce CYP3A4 and P-gp 2, 1
Semaglutide (Ozempic) is not known to interact with any of these pathways in a clinically significant manner.
Important Monitoring Considerations
While these medications can be used together safely, there are some monitoring considerations to be aware of:
Blood Glucose Monitoring
- Clearance of HCV infection with direct-acting antivirals like Maviret may lead to improved hepatic function, which can affect blood glucose control 1
- This improved hepatic function may enhance the glucose-lowering effect of Ozempic
- Monitor blood glucose levels during and after HCV treatment, as dosage adjustments of Ozempic may be needed 2
Common Side Effects to Be Aware Of
Ozempic (Semaglutide):
- Transient nausea and vomiting (relatively common)
- Can be minimized by starting with the lowest dose and up-titrating gradually
- Usually self-limited with longer-acting GLP-1RAs 2
Maviret (Glecaprevir/Pibrentasvir):
- Headache and fatigue are most commonly reported adverse events 2, 3
- Well-tolerated in clinical trials with discontinuation rates due to adverse events less than 1% 3
Special Populations
Both medications have been studied in patients with renal impairment:
- Maviret requires no dose adjustment in patients with any degree of renal impairment 2, 4
- Ozempic can be used in renal impairment with appropriate monitoring
For patients with hepatic impairment:
- Maviret is safe in patients with compensated (Child-Pugh A) cirrhosis 4
- Maviret should not be used in patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment 2, 4
Patient Message
Dear Patient,
Good news! It is safe to take your Ozempic (semaglutide) and Maviret (glecaprevir/pibrentasvir) medications together. There are no known significant interactions between these two medications that would prevent you from using them at the same time.
A few things to keep in mind:
- Continue to monitor your blood sugar levels regularly, as treating hepatitis C can sometimes improve your body's response to diabetes medications
- Let us know if you experience any new or worsening side effects
- Take your Maviret with food as directed
- Continue your Ozempic injections as prescribed
Please don't hesitate to reach out if you have any questions or concerns.
Best regards, Your Healthcare Provider