What is the equivalent dosage of 0.3 mL of 200 mg/mL testosterone enanthate to testosterone cypionate 100 mg/mL?

From the Guidelines

To convert 0.3 mL of testosterone enanthate 200 mg/mL to testosterone cypionate 100 mg/mL, you would need 0.6 mL of testosterone cypionate. This calculation is based on the principle that both medications are testosterone esters with similar potency, and thus, the same amount of active hormone is required for an equivalent therapeutic effect. First, calculate the total amount of testosterone enanthate: 0.3 mL × 200 mg/mL = 60 mg, as seen in the dosage supplied column of Table 3 in the study by 1. Since both medications are testosterone esters, you need the same amount of active hormone. With testosterone cypionate at 100 mg/mL, you would need 60 mg ÷ 100 mg/mL = 0.6 mL to deliver an equivalent dose.

Key Considerations

• The conversion maintains the same therapeutic effect because both testosterone esters provide similar androgenic and anabolic effects once metabolized in the body, despite having slightly different half-lives, as noted in the advantages and disadvantages of long-acting injections in the study by 1.
• The cypionate ester has a slightly longer half-life than enanthate, but this difference is not clinically significant for most administration schedules, as indicated by the typical dose range for both testosterone enanthate and testosterone cypionate in the study by 1.
• When performing this conversion, it is crucial to use a proper insulin syringe or tuberculin syringe with appropriate markings to ensure accurate measurement of the 0.6 mL dose, considering the application site and advantages of each formulation, as outlined in the study by 1.

Administration and Monitoring

• The administration of testosterone cypionate should be based on the individual patient's needs, considering factors such as the application site, advantages, and disadvantages of each formulation, as discussed in the study by 1.
• Monitoring of the patient's response to the converted dose is essential to ensure the therapeutic effect is maintained and to adjust the dose as necessary, taking into account the potential for fluctuating serum testosterone levels with peaks and valleys, as mentioned in the study by 1.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION Testosterone Cypionate Injection is for intramuscular use only. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; For replacement in the hypogonadal male, 50-400 mg should be administered every two to four weeks

The FDA drug label does not answer the question.

From the Research

Equivalent Dosage of Testosterone Enanthate and Testosterone Cypionate

To determine the equivalent dosage of 0.3 mL of 200 mg/mL testosterone enanthate to testosterone cypionate 100 mg/mL, we need to calculate the amount of testosterone in each formulation.

• Testosterone enanthate: 0.3 mL x 200 mg/mL = 60 mg
• Testosterone cypionate: to find the equivalent dosage, we need to consider the potency and bioavailability of both formulations. However, the provided studies do not directly compare the potency and bioavailability of testosterone enanthate and testosterone cypionate 2, 3, 4, 5, 6.

Comparison of Testosterone Formulations

While the studies do not provide a direct comparison of the equivalent dosages, they do discuss the efficacy and safety of different testosterone formulations. For example, a study comparing intramuscular testosterone cypionate with subcutaneous testosterone enanthate found that both formulations increased total testosterone levels, but subcutaneous testosterone enanthate was associated with lower levels of estradiol and hematocrit 5.

Calculation of Equivalent Dosage

Based on the available information, we can calculate the equivalent dosage of testosterone cypionate based on the amount of testosterone in the testosterone enanthate formulation.

• Testosterone cypionate: 60 mg (equivalent to 0.3 mL of 200 mg/mL testosterone enanthate) / 100 mg/mL = 0.6 mL

Therefore, the equivalent dosage of 0.3 mL of 200 mg/mL testosterone enanthate to testosterone cypionate 100 mg/mL is 0.6 mL. However, please note that this calculation is based on the assumption that the potency and bioavailability of both formulations are similar, which may not be the case 2, 3, 4, 5, 6.