From the Research
Tretinoin may be effective in improving the appearance of stretch marks, particularly newer ones, as evidenced by a study published in 1996 1. The use of tretinoin for treating stretch marks has been explored in various studies, with some showing promising results.
- A study published in 1996 found that topical 0.1% tretinoin cream significantly improved the clinical appearance of early, active stretch marks compared to vehicle treatment 1.
- However, a more recent review published in 2019 noted that despite several advances, no fully effective treatment has emerged for stretch marks, and the evidence for tretinoin's effectiveness is limited 2.
- Another study published in 2014 found that the evidence for interventions to treat stretch marks is insufficient to provide clear guidelines for practice, highlighting the need for more high-quality research 3.
- A study comparing topical therapy for striae alba found that 20% glycolic acid combined with 0.05% tretinoin emollient cream can improve the appearance of stretch marks, increase elastin content, and increase epidermal thickness 4.
When using tretinoin to treat stretch marks, it is essential to:
- Apply a pea-sized amount of 0.025% to 0.1% tretinoin cream to affected areas once daily before bedtime
- Continue treatment for at least 3-6 months to see improvement
- Start with the lower concentration and gradually increase if tolerated, as tretinoin commonly causes irritation, redness, and peeling
- Apply sunscreen during the day as tretinoin increases sun sensitivity
- Consider combining tretinoin with other treatments like microneedling or laser therapy under dermatological supervision
- Discontinue use if severe irritation occurs and consult a dermatologist for persistent or extensive stretch marks.