What are the symptoms of Myalgic Encephalomyelitis (ME) or Myasthenia gravis (MG)?

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From the Guidelines

Myalgic Encephalomyelitis (ME) and Myasthenia Gravis (MG) present with distinct symptoms, including severe fatigue, muscle weakness, and pain, with ME/CFS literature suggesting postexertional malaise, cognitive dysfunction, and immune dysfunction as key symptoms 1. The symptoms of ME include postexertional malaise, cognitive dysfunction, and immune dysfunction, as outlined in the ME/CFS literature 1. In contrast, Myasthenia Gravis (MG) is characterized by muscle weakness, particularly in the proximal extremities, with difficulties in standing up, lifting arms, and moving around, as well as myalgia in severe cases 1. Some key symptoms of ME and MG include:

  • Postexertional malaise
  • Cognitive dysfunction
  • Immune dysfunction
  • Muscle weakness, particularly in the proximal extremities
  • Myalgia
  • Fatigue
  • Pain
  • Dysautonomia It is essential to note that the symptoms of ME and MG can be similar to those of other conditions, such as polymyalgia rheumatica, inflammatory myositis, and fibromyalgia, making diagnosis challenging 1. The most recent and highest quality study, published in 2023, provides a comprehensive overview of the symptoms and treatment options for ME/CFS, which can be applied to the management of ME and MG 1.

From the Research

Symptoms of Myalgic Encephalomyelitis (ME) or Myasthenia Gravis (MG)

There are no research papers provided to assist in answering this question about the symptoms of Myalgic Encephalomyelitis (ME) or Myasthenia Gravis (MG). The studies provided are related to Macrophage Activation Syndrome (MAS) and do not discuss ME or MG.

Symptoms of Macrophage Activation Syndrome (MAS)

  • Fever 2, 3, 4, 5, 6
  • Hepatosplenomegaly 2, 3, 4, 5, 6
  • Lymphadenopathy 2, 3, 5, 6
  • Pancytopenia 2, 3, 5, 6
  • Coagulopathy 2, 3, 4, 5
  • Hyperferritinemia 4, 5, 6
  • Hypertriglyceridemia 2, 4, 5
  • Neurological symptoms 6
  • Cutaneous and mucosal bleeding 5
  • Central nervous system, cardiac, and renal involvement 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Macrophage activation syndrome: early diagnosis is key.

Open access rheumatology : research and reviews, 2018

Research

Macrophage activation syndrome: A diagnostic challenge (Review).

Experimental and therapeutic medicine, 2021

Research

Macrophage activation syndrome: a frequent but under-diagnosed complication associated with rheumatic diseases.

Medical science monitor : international medical journal of experimental and clinical research, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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