From the Guidelines

Fever treatment options beyond Tylenol (Acetaminophen) include ibuprofen.

Ibuprofen: can be used as an antipyretic, with a recommended dose of 0.2 g orally every 4-6 hours, not exceeding 4 times in 24 hours, as stated in the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia 1.
Other considerations: the use of antipyretic medications, such as ibuprofen, should be based on individual patient needs and preferences, particularly for comfort and symptomatic relief, as suggested by the Society of Critical Care Medicine and the Infectious Diseases Society of America guidelines for evaluating new fever in adult patients in the ICU 1.

Fever management: reducing body temperature may not necessarily improve outcomes, and the routine use of antipyretic medications for this purpose is not recommended, as indicated by the guidelines for evaluating new fever in adult patients in the ICU 1.
Patient-specific approach: treatment decisions should be tailored to the individual patient's condition, taking into account their specific needs, preferences, and underlying health status, as emphasized in the guidelines for managing COVID-19 symptoms in the community 1.

From the Research

If a patient's fever is unresponsive to Tylenol (Acetaminophen), alternative treatment options can be considered, including:
- Ibuprofen: Studies have shown that ibuprofen can be effective in reducing fever and pain in patients who are unresponsive to acetaminophen 2, 3, 4, 5
- Aspirin: Aspirin has been shown to be effective in reducing fever and other symptoms of upper respiratory tract infection in adults 4
- Physical cooling methods: Physical cooling methods, such as the use of a cooling blanket, can be used in conjunction with antipyretics to reduce fever 6
The choice of treatment will depend on the individual patient's needs and medical history, as well as the underlying cause of the fever
It is essential to consult with a healthcare professional to determine the best course of treatment for a patient with fever who is unresponsive to Tylenol (Acetaminophen)

Studies have compared the efficacy of different treatment options for fever, including:
- Acetaminophen vs. ibuprofen: Ibuprofen has been shown to be more effective in reducing fever and pain in some studies 2, 5
- Acetaminophen vs. aspirin: Aspirin has been shown to be effective in reducing fever and other symptoms of upper respiratory tract infection in adults, but its use may be limited by potential side effects 4
- Combination therapy: Combination therapy with acetaminophen and ibuprofen has been shown to be effective in reducing fever and pain in some studies 2, 3

The safety and efficacy of different treatment options for fever have been evaluated in various studies, including:
- Ibuprofen: Ibuprofen has been shown to be generally safe and effective in reducing fever and pain in children and adults 2, 5
- Aspirin: Aspirin has been shown to be effective in reducing fever and other symptoms of upper respiratory tract infection in adults, but its use may be limited by potential side effects 4
- Acetaminophen: Acetaminophen is generally considered safe and effective in reducing fever and pain, but its use may be limited by potential side effects, such as liver damage 6, 3