From the Research
A vitamin B12 injection is unlikely to be the primary cause of panic attacks and derealization the next day, as there is no high-quality evidence to support a direct link between vitamin B12 supplementation and these symptoms. However, it is possible that the injection may trigger anxiety symptoms in sensitive individuals due to its stimulatory effect on the central nervous system 1. Additionally, vitamin B12 plays a role in neurotransmitter synthesis, including those that regulate mood and anxiety like serotonin and dopamine, and a sudden increase in these neurotransmitters could disrupt the normal balance and trigger anxiety symptoms 2.
Some patients may also experience a paradoxical reaction to B12, where instead of feeling better, they experience increased anxiety, which is more likely in patients with pre-existing anxiety disorders or those sensitive to stimulants 1. The injection method itself delivers B12 rapidly into the bloodstream, which might cause a more pronounced effect compared to oral supplements 3.
If you've experienced this reaction, it is essential to consult with your healthcare provider before receiving further B12 injections. They might recommend a lower dose, switching to oral supplements, or addressing any underlying anxiety conditions first 4. It is also crucial to note that patient-centered care and treating patients with dignity and respect is a policy priority to reduce unsafe health behaviors, such as self-medication via injection 4.
Key considerations for healthcare providers include:
- Being aware of the potential for anxiety symptoms in sensitive individuals
- Monitoring patients for adverse reactions to vitamin B12 injections
- Considering alternative treatment options, such as oral supplements, for patients who experience anxiety symptoms
- Providing patient-centered care and addressing underlying anxiety conditions to reduce unsafe health behaviors.