From the Research
NAD+ IV infusions should be administered once or twice weekly during an initial treatment phase, followed by maintenance sessions every 2-4 weeks, as this frequency has been shown to be effective in maintaining elevated NAD+ levels and improving health outcomes 1. The frequency of NAD+ IV infusions depends on individual health goals, age, and specific conditions being addressed.
- A standard protocol might include 4-10 initial sessions (often daily or every other day), then transitioning to less frequent maintenance treatments.
- Each infusion generally lasts 2-4 hours, with dosages ranging from 500-1000mg per session. However, there is limited standardization in protocols as NAD+ therapy is still considered experimental. The rationale for spacing treatments is to maintain elevated NAD+ levels, which naturally decline with age and are associated with cellular energy production and DNA repair. It's essential to note that NAD+ IV therapy should only be administered by qualified healthcare providers, as improper administration can cause side effects like flushing, nausea, or headaches. Before starting NAD+ infusions, patients should consult with a healthcare provider to determine an appropriate schedule based on their specific health needs and medical history, as supported by recent studies 2, 3. Additionally, research has shown that NAD+ supplementation can have beneficial effects on physiological changes and diseases associated with aging, including chronic fatigue syndrome, older adults, Parkinson's disease, overweight, postmenopausal prediabetes, and Alzheimer's disease 1, 4. A recent study also investigated the changes in human plasma and urine NAD+ metabolome during a 6-hour intravenous infusion of NAD+, providing valuable insights into the fate of directly infused NAD+ in humans 5.