Treatment for Jellyfish Sting
For jellyfish stings, immediately decontaminate the area with vinegar (4-6% acetic acid solution) for at least 30 seconds to inactivate remaining nematocysts, then immerse the affected area in hot water (as hot as tolerated, approximately 40°C/104°F) for 20-30 minutes for pain management. 1
Initial Management
Remove from water and ensure safety
Decontaminate the wound:
Pain management:
What to Avoid
- DO NOT use:
Follow-up Care
Wound care:
When to seek emergency care - if the patient develops:
- Difficulty breathing
- Signs of shock
- Severe pain
- Systemic symptoms 1
Species-Specific Considerations
Treatment efficacy may vary depending on jellyfish species. While vinegar is generally recommended, it may cause pain exacerbation in some North American species 5. Hot water immersion appears more universally beneficial for pain relief across species 5.
Evidence Quality and Controversies
The most recent guidelines from the American Heart Association and American Red Cross (via Praxis Medical Insights, 2025) provide the strongest recommendations 1. However, there remains some controversy in the literature regarding optimal treatments, particularly for different jellyfish species 6, 4, 5.
The 2010 AHA guidelines specifically recommend hot water immersion for pain relief, which is supported by more recent evidence 2, 1. The effectiveness of lidocaine has gained support in recent research, showing it both relieves pain and may prevent further nematocyst discharge 3.
While vinegar is widely recommended for initial decontamination, its effectiveness may vary by species, highlighting the importance of regional treatment protocols 6, 5.