From the Guidelines
Amlodipine, a calcium channel blocker, can cause constipation as a side effect, as noted in the most recent and highest quality study available 1. When considering the potential side effects of amlodipine, it's essential to weigh the benefits of the medication against the risks. Amlodipine is primarily used to treat high blood pressure and certain types of chest pain.
- The study published in the European Heart Journal in 2022 1 mentions that non-dihydropyridine calcium channel blockers can cause constipation, among other side effects.
- However, it's crucial to note that the study does not provide a specific percentage of patients who experience constipation while taking amlodipine.
- To manage constipation caused by amlodipine, patients can try staying well-hydrated, increasing dietary fiber, engaging in regular physical activity, and maintaining a consistent bathroom routine.
- If constipation persists, patients should consult their healthcare provider, who may recommend a stool softener or mild laxative, adjust the amlodipine dosage, or consider an alternative medication.
- It's essential not to stop taking amlodipine without consulting a doctor, as uncontrolled high blood pressure poses greater health risks than constipation 1.
From the Research
Amlodipine and Constipation
- Amlodipine, a calcium channel blocker, has been studied for its effects on bowel habits in patients with hypertension 2.
- One study found that the relative risk of developing constipation was 4 times more in patients taking amlodipine alone compared to those taking a combination of amlodipine and atenolol 2.
- Another study compared the pharmacological properties of different calcium channel blockers, including amlodipine, and noted that verapamil may cause constipation, but did not mention amlodipine as a cause of constipation 3.
- A review of amlodipine's use in hypertension management listed its side effects, including edema, palpitations, dizziness, and flushing, but did not mention constipation 4.
- A study on the safety of amlodipine found that it had a favorable safety profile compared to beta-blockers and other calcium antagonists, and that constipation was more common in patients receiving verapamil than amlodipine 5.
- A reappraisal of amlodipine's pharmacological properties and therapeutic use noted that vasodilator adverse events such as edema, headaches, and flushing were commonly observed, but did not mention constipation as a side effect 6.