From the FDA Drug Label
DOSAGE AND ADMINISTRATION - ADULTS Intra-Abdominal* Complicated 500 mg q 12 h 7 to 14 Days
The recommended dose of Cipro (ciprofloxacin) for diverticulitis (which is a type of intra-abdominal infection) is 500 mg every 12 hours for 7 to 14 days, used in conjunction with metronidazole. 1
From the Research
For diverticulitis, Ciprofloxacin (Cipro) is typically prescribed at a dose of 500 mg orally twice daily for 7-10 days, in combination with metronidazole 500 mg orally three times daily, as supported by the most recent and highest quality study 2.
Key Considerations
- The dosage may need adjustment for patients with kidney impairment.
- It's essential to take the full course of antibiotics even if symptoms improve before completion.
- Cipro works by inhibiting bacterial DNA gyrase, preventing bacterial cell reproduction.
- Patients should stay well-hydrated while taking Cipro and avoid antacids, dairy products, and calcium supplements within 2 hours of taking the medication as these can reduce absorption.
Safety and Efficacy
- Outpatient treatment with oral antibiotics has been shown to be safe and effective in treating uncomplicated acute diverticulitis, with a success rate of over 92% 2.
- Common side effects include nausea, diarrhea, and headache.
- Cipro carries a risk of tendon damage, so patients should avoid strenuous physical activity during treatment and report any tendon pain immediately.
Treatment Protocol
- The treatment protocol typically consists of oral antibiotics for 7-10 days, a liquid diet, and oral analgesics.
- Patients with severe cases requiring hospitalization may receive intravenous Cipro at 400 mg every 12 hours.
- The choice of antibiotic regimen may vary depending on the patient's condition and medical history, but the combination of Cipro and metronidazole is a commonly recommended regimen 2, 3.