From the Guidelines
Low-level laser therapy (LLLT) or photobiomodulation (PBM) may be effective in reducing facial rhytides (wrinkles), but the current evidence is limited and more research is needed to fully understand its effects. The use of LLLT or PBM for wrinkle reduction involves the application of low-level red light wavelengths (typically 630-700 nm) to penetrate the skin and potentially stimulate collagen production, improve circulation, and reduce inflammation. For wrinkle reduction, treatments typically involve 10-20 minute sessions, 3-5 times weekly for 4-12 weeks, with maintenance sessions thereafter 1.
Some key points to consider when using LLLT or PBM for wrinkle reduction include:
- The treatment is non-invasive and generally considered safe with minimal side effects
- Results vary by individual, with some seeing modest improvements in fine lines, skin texture, and overall appearance
- The therapy works by energizing cellular mitochondria, which may accelerate healing and tissue repair processes
- Professional treatments at dermatology offices typically offer stronger devices than at-home options, though quality home devices can also be effective with consistent use
- LLLT or PBM should be part of a comprehensive skincare routine that includes sun protection, proper hydration, and other anti-aging strategies
It is essential to note that the current evidence for LLLT or PBM in reducing facial rhytides is limited, and more research is needed to fully understand its effects. A small randomized split-face study of PDT (MAL 1 and 3 h, 630 nm, 37 J cm−2) in 10 patients with moderate photo-damage found an improvement in skin quality and fine wrinkling, although details on methodology and statistical analysis are not provided 1. Therefore, while LLLT or PBM may be a promising treatment for reducing facial rhytides, it should be used with caution and in conjunction with other skincare strategies.
From the Research
Effectiveness of Low-Level Laser Therapy (LLLT) or Photobiomodulation (PBM) for Treating Facial Rhytides (Wrinkles)
- LLLT using 660 nm LEDs or 411 to 777 nm LEDs significantly improved periocular wrinkles, with the 660 nm LEDs showing slightly better improvement 2
- PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction 3
- LED phototherapy using 830nm and 633nm LEDs is an effective approach for skin rejuvenation, with significant reductions in wrinkles and increases in skin elasticity 4
- Low-level red plus near infrared lights combination induces expressions of collagen and elastin in human skin in vitro, suggesting an effective treatment opportunity for people with photo-aged skin 5
- Combination LED light therapy (633 nm and 830 nm) is an effective and acceptable method of photo rejuvenation, with significant improvements in photoaging scores and patient satisfaction 6
Key Findings
- Red and amber PBM reduces periocular wrinkle volume by 30% 3
- 660 nm LEDs could be an effective and tolerable treatment option for wrinkles 2
- LED phototherapy increases the amount of collagen and elastic fibers, and improves skin elasticity 4
- Low-level red plus near infrared lights combination stimulates the production of collagen and elastin, associated with anti-ageing benefits 5
- Combination LED light therapy improves photoaging scores and patient satisfaction 6
Treatment Parameters
- 660 nm LEDs or 411 to 777 nm LEDs, 5.17 J, daily for 12 weeks 2
- Red (660 nm) and amber (590 nm) PBM, 3.8 J/cm2, 10 sessions for 4 weeks 3
- 830nm and 633nm LEDs, twice a week for four weeks 4
- Low-level red plus near infrared lights combination, 0.5 mW/cm2, 10 minutes (0.3 J/cm2), daily 5
- Combination LED light therapy (633 nm and 830 nm), 126 J/cm(2) and 66 J/cm(2) respectively, nine treatments 6