How many units of Actrapid (fast-acting insulin) should be given for a CBG (capillary blood glucose) of 330 mg/dL on a sliding scale?

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Sliding Scale Insulin Dosing for CBG of 330 mg/dL

For a capillary blood glucose (CBG) of 330 mg/dL, 8 units of Human Actrapid insulin should be administered as per standard sliding scale protocols. 1

Rationale for Dosing Decision

The recommended correction insulin protocol for elevated blood glucose levels follows a tiered approach:

  • For CBG 251-300 mg/dL: 6 units
  • For CBG >300 mg/dL: 8 units 1

Since the patient's CBG is 330 mg/dL, which is >300 mg/dL, the appropriate dose is 8 units of Human Actrapid insulin.

Important Considerations When Using Sliding Scale Insulin

Limitations of Sliding Scale Approach

While sliding scale insulin is commonly used in hospitals, it has significant limitations:

  • Treats hyperglycemia reactively rather than preventively 2
  • Often used without modification throughout hospital stays despite poor control 2
  • Associated with higher rates of hyperglycemic episodes when used alone 3
  • May lead to rapid fluctuations in blood glucose levels 2

Monitoring Requirements

After administering the correction dose:

  • Monitor blood glucose every 1-2 hours until glucose values stabilize 2
  • Once stable, monitor every 4 hours 2
  • Be cautious with point-of-care testing of capillary blood as it may not accurately reflect arterial blood glucose values 2

Risk of Hypoglycemia

When using sliding scale insulin, be vigilant for hypoglycemia:

  • If blood glucose drops below 70 mg/dL, stop insulin and administer 25g of glucose 1
  • Recheck blood glucose in 15 minutes 1
  • African American race and low serum albumin are independent risk factors for hypoglycemic episodes 3

More Effective Approaches to Consider

For ongoing management, consider transitioning from sliding scale alone to a more effective regimen:

  • Basal-bolus insulin therapy has shown better glycemic control than sliding scale alone 2, 4
  • For patients with established insulin requirements, sliding scale monotherapy is ineffective 2
  • A basal-plus approach (basal insulin with correction doses) may be preferred for patients with mild hyperglycemia or decreased oral intake 2

Implementation Tips

  • Verify the elevated glucose reading with a second measurement before administering insulin 1
  • Document administration time and dose carefully to avoid errors 5
  • If hyperglycemia persists despite sliding scale insulin, consider adjusting the regimen or adding basal insulin 2
  • For persistent hyperglycemia (>180 mg/dL), a protocolized approach to blood glucose management is recommended 2

Remember that while the immediate action is to administer 8 units of Human Actrapid for the CBG of 330 mg/dL, ongoing assessment of the patient's glycemic control and insulin regimen is essential for optimal outcomes.

References

Guideline

Insulin Therapy in Adult Patients with Diabetes

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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