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Differential Diagnosis for a 37-year-old Patient with Right Testicular Pain and Swelling

Single Most Likely Diagnosis

  • Epididymitis: This is the most likely diagnosis given the patient's symptoms of testicular pain and swelling. Epididymitis is an inflammation of the epididymis, often caused by bacterial infection, and is common in sexually active men. The patient's history of diabetes (DM) may also increase the risk of infections.

Other Likely Diagnoses

  • Orchitis: Inflammation of one or both testicles, usually caused by bacterial or viral infections. It can present with testicular pain and swelling, similar to epididymitis.
  • Testicular Torsion: Although less likely given the duration of symptoms (two weeks), testicular torsion is a condition where the spermatic cord becomes twisted, cutting off the blood supply to the testicle. It typically presents with sudden, severe pain.
  • Hydrocele: An accumulation of fluid in the tunica vaginalis, a potential space around the testicle, which can cause swelling but usually not significant pain.

Do Not Miss Diagnoses

  • Testicular Cancer: Although rare, testicular cancer can present with a painless testicular mass or swelling. Given the potential for serious outcomes if missed, it's crucial to consider this diagnosis.
  • Acute Appendicitis (with an atypical presentation): In rare cases, appendicitis can present with testicular pain if the inflamed appendix is located near the testicle, causing referred pain.

Rare Diagnoses

  • Spermatocele: A cystic structure filled with sperm, which can cause swelling but is usually painless.
  • Varicocele: An enlargement of the veins within the scrotum, similar to varicose veins, which can cause a sensation of swelling or heaviness but is typically not painful.
  • Henoch-Schönlein Purpura (HSP): A form of vasculitis that can cause testicular pain and swelling, among other symptoms, but is relatively rare and usually associated with other systemic symptoms like purpura and joint pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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