Can I take Wegovy (semaglutide) and vitamin D 1.25mg on the same day?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 16, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

You can generally take Wegovy (semaglutide) and vitamin D 1.25mg on the same day, as there are no known significant interactions between these medications. Wegovy is an injectable medication used for weight management that works by mimicking a hormone called GLP-1, while vitamin D is a fat-soluble vitamin important for bone health and immune function. Take each medication as prescribed by your healthcare provider - Wegovy is typically injected once weekly, while vitamin D supplements are usually taken daily. It's worth noting that 1.25mg (50,000 IU) of vitamin D is a high dose, typically prescribed for vitamin D deficiency treatment rather than regular supplementation, and is often given weekly or monthly rather than daily 1. Always follow your doctor's specific instructions regarding timing and dosage for both medications. If you experience any unusual side effects after taking them together, contact your healthcare provider for guidance.

Key Points to Consider

  • The primary mechanism of action of semaglutide is through GLP-1 receptor agonism, which helps in weight management by reducing appetite and increasing feelings of fullness 2, 3.
  • Vitamin D is essential for bone health and immune function, and its supplementation is common in individuals with deficiency or insufficiency 1.
  • The safety and efficacy of semaglutide for weight management have been established in several clinical trials, including the STEP trials 4, 1.
  • While there are no direct interactions between semaglutide and vitamin D, monitoring for any adverse effects and adjusting the treatment plan as necessary is crucial 5, 1.

Recommendations for Use

  • Follow the prescribed dosage and administration schedule for both Wegovy (semaglutide) and vitamin D supplements.
  • Be aware of the potential side effects of both medications and report any unusual symptoms to your healthcare provider.
  • Regularly review and adjust your treatment plan with your healthcare provider to ensure the best outcomes for your weight management and overall health.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.