Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 19, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

ECG Interpretation Differential Diagnosis

Given the task to interpret an ECG, the differential diagnosis can be broad and varied, depending on the specific findings on the ECG. However, without a specific ECG tracing provided, we'll approach this by considering common and critical diagnoses that could be encountered.

  • Single Most Likely Diagnosis
    • Normal Variant: Many ECGs are interpreted as normal variants, especially in asymptomatic individuals. This diagnosis is likely if the ECG shows no significant abnormalities.
  • Other Likely Diagnoses
    • Hypertension-related Changes: Left ventricular hypertrophy (LVH) is a common finding in patients with hypertension, which can be detected on an ECG.
    • Atrial Fibrillation: A common arrhythmia, especially in older adults, characterized by an irregularly irregular rhythm.
    • Ventricular Ectopy: Premature ventricular contractions (PVCs) are common and can be seen in healthy individuals as well as those with heart disease.
  • Do Not Miss Diagnoses
    • Acute Myocardial Infarction (MI): ST-elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI) must be quickly identified due to the need for urgent intervention.
    • Pulmonary Embolism: While the ECG is not definitive for pulmonary embolism, certain patterns (e.g., S1Q3T3 pattern, right bundle branch block) can suggest this diagnosis.
    • Cardiac Tamponade: Electrical alternans or low QRS voltage can be indicative of a life-threatening tamponade.
  • Rare Diagnoses
    • Brugada Syndrome: Characterized by specific ST-segment elevations in leads V1-V3, which can lead to sudden cardiac death.
    • Long QT Syndrome: Prolongation of the QT interval can predispose to torsades de pointes, a potentially fatal arrhythmia.
    • Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): Characterized by epsilon waves and T-wave inversion in the right precordial leads, associated with an increased risk of ventricular arrhythmias.

Each of these diagnoses has distinct ECG features, and the interpretation depends on recognizing these patterns. The clinical context (e.g., patient symptoms, medical history) is also crucial in narrowing down the differential diagnosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.