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Last updated: September 20, 2025View editorial policy

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Differential Diagnosis for Appendicular Lump

  • Single most likely diagnosis
    • Appendicular mass (phlegmon or abscess): This is the most likely diagnosis due to the location and presentation of the lump. An appendicular mass forms as a result of the body's attempt to localize and contain an appendiceal infection, leading to a palpable mass in the right lower quadrant.
  • Other Likely diagnoses
    • Intussusception: Although more common in children, intussusception can occur in adults and may present as a palpable mass if it involves the terminal ileum and appendix.
    • Meckel's diverticulum: If a Meckel's diverticulum becomes inflamed or obstructed, it can present as a lump in the right lower quadrant, mimicking an appendicular mass.
    • Ileocecal tuberculosis: This condition can cause a mass in the right lower quadrant due to inflammation and scarring of the ileocecal region.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Carcinoid tumor: Although rare, a carcinoid tumor of the appendix can present as a lump and has significant implications for treatment and prognosis.
    • Appendiceal carcinoma: Primary carcinoma of the appendix is rare but can present as a mass and requires prompt diagnosis and treatment.
    • Ovarian torsion (in females): While not directly related to the appendix, ovarian torsion can present with acute abdominal pain and a palpable mass, making it a critical diagnosis not to miss.
  • Rare diagnoses
    • Gastrointestinal stromal tumor (GIST) of the small intestine: A GIST can rarely present as a lump in the right lower quadrant if it involves the terminal ileum.
    • Lymphoma involving the appendix or ileocecal region: Lymphoma can cause a mass in this region, although it is a rare occurrence.
    • Metastatic disease to the appendix: Rarely, metastatic cancer can involve the appendix and present as a lump.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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