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Last updated: September 21, 2025View editorial policy

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Differential Diagnosis for a Baby with a Runny Nose and Resolved Fever

Single Most Likely Diagnosis

  • URTI (Upper Respiratory Tract Infection): This is the most likely diagnosis given the symptoms of a runny nose for 2 weeks and a resolved fever. URTIs are common in infants and can persist for up to 2 weeks. The resolution of fever further supports this diagnosis, as URTIs typically do not lead to severe complications like sinusitis in the initial stages.

Other Likely Diagnoses

  • Sinusitis: Although less likely than URTI given the duration and resolution of fever, sinusitis is a possible diagnosis, especially if the runny nose is persistent and accompanied by other symptoms such as nasal congestion, cough, or facial pain (though these might be harder to assess in a baby).
  • Allergic Rhinitis: This could be considered if the baby is exposed to allergens and the runny nose persists without other symptoms of infection. However, in a 2-week timeframe, especially with an initial fever, this is less likely.

Do Not Miss Diagnoses

  • Bacterial Sinusitis: Although less common, bacterial sinusitis can occur, especially if the symptoms worsen or do not improve with time. It's crucial to consider this diagnosis to avoid missing a potentially serious infection that requires antibiotic treatment.
  • Invasive Bacterial Infections: In rare cases, what appears to be a simple URTI can be a precursor to more serious infections like meningitis or sepsis, especially in very young infants. While unlikely, these conditions are medical emergencies.

Rare Diagnoses

  • Immunodeficiency: A persistent runny nose could, in rare cases, be a sign of an underlying immunodeficiency, where the body's ability to fight off common infections is compromised.
  • Anatomical Abnormalities: Rare congenital abnormalities of the nasal passages or sinuses could lead to persistent nasal discharge. These would typically be associated with other symptoms or findings on physical examination.
  • Tumor or Cyst: Although extremely rare in infants, a tumor or cyst in the nasal passages could cause persistent nasal symptoms. This would be considered if other diagnoses are ruled out and if there are additional symptoms such as nasal obstruction or facial deformity.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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