Bartholin's cyst: This is a common condition where a cyst forms on the labia majora due to a blocked Bartholin's gland. It is usually painful and can become infected, leading to an abscess.

Folliculitis: An inflammation of the hair follicles, which can cause bumps on the labia majora. It's often caused by bacterial or fungal infections.
Ingrown hair: A condition where hair grows back into the skin, causing inflammation, redness, and a bump.
Sebaceous cyst: A benign, usually painless, cyst that forms from blocked oil glands in the skin.
Genital warts: Caused by the human papillomavirus (HPV), these can appear as bumps on the labia majora.

Squamous cell carcinoma: A type of skin cancer that can present as a bump on the labia majora. Early detection is crucial for effective treatment.
Malignant melanoma: Although rare in the genital area, it's a serious form of skin cancer that requires prompt diagnosis and treatment.
Herpes simplex virus (HSV): Can cause painful bumps or blisters on the labia majora, which can be mistaken for other conditions.

Hidradenitis suppurativa: A chronic skin condition that can cause painful bumps and abscesses in the groin area, including the labia majora.
Vulvar intraepithelial neoplasia (VIN): Abnormal cell growth on the vulva that can progress to cancer if not treated.
Molluscum contagiosum: A viral infection that causes small, pearly, or flesh-colored bumps on the skin, including the genital area.