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Differential Diagnosis for Shoulder Pain and Difficulty with Overhead Abduction

Single Most Likely Diagnosis

  • Rotator Cuff Tendinitis or Tear: This condition is the most common cause of shoulder pain and difficulty with movements such as picking things up and overhead abduction. The rotator cuff is a group of muscles and tendons that surround the shoulder joint, and injuries to this area can lead to significant pain and functional impairment.

Other Likely Diagnoses

  • Adhesive Capsulitis (Frozen Shoulder): Characterized by stiffness and pain in the shoulder joint, adhesive capsulitis can significantly limit movement and is a common cause of difficulty with overhead activities.
  • Subacromial Bursitis: Inflammation of the bursa that cushions the rotator cuff tendons can cause pain and limit movement, especially with overhead activities.
  • Osteoarthritis of the Shoulder: Wear and tear on the shoulder joint can lead to pain and stiffness, affecting the ability to perform overhead movements.

Do Not Miss Diagnoses

  • Axillary Nerve Injury or Compression: While less common, injury or compression of the axillary nerve can cause significant shoulder dysfunction and must be considered to avoid missing a potentially treatable condition.
  • Thoracic Outlet Syndrome: Compression of the nerves and/or blood vessels that pass into the thoracic outlet can cause shoulder pain and weakness, and is a critical diagnosis not to miss due to its potential for serious complications if left untreated.
  • Infection or Septic Arthritis: Although rare, infection within the shoulder joint is a medical emergency that requires prompt diagnosis and treatment to prevent serious complications.

Rare Diagnoses

  • Polymyalgia Rheumatica: An inflammatory condition that affects the muscles, particularly around the shoulders, and can cause significant pain and stiffness.
  • Avascular Necrosis of the Humeral Head: A condition where the blood supply to the humeral head is interrupted, leading to bone death and potentially severe shoulder pain and dysfunction.
  • Tumors (Benign or Malignant): While extremely rare, tumors affecting the shoulder region can cause pain and limited mobility, and must be considered in the differential diagnosis to ensure timely and appropriate treatment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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