From the Research
The recommended loading phase for subcutaneous NAD administration is daily injections of 100-200mg NAD+ for 5-10 days, followed by a maintenance regimen of 100-200mg NAD+ administered subcutaneously 1-3 times per week, depending on individual response and needs, as supported by the most recent and highest quality study available 1. The subcutaneous route offers better bioavailability compared to oral supplementation, as it bypasses first-pass metabolism in the liver. Proper administration technique is essential - injections should be given into the fatty tissue of the abdomen, thigh, or back of the arm using a small insulin syringe (typically 29-31 gauge). Injection sites should be rotated to prevent tissue irritation. Some patients may experience mild burning or redness at the injection site, which typically resolves quickly. NAD+ supplementation works by replenishing cellular NAD+ levels, which decline with age and in various disease states, thereby supporting mitochondrial function, DNA repair mechanisms, and cellular energy production. Individual response varies, so dosing may need adjustment based on symptomatic improvement and tolerance.
Key Considerations
- The most recent study on NAD supplementation, published in 2022, found that oral administration of nicotinamide mononucleotide (NMN) is safe and efficiently increases blood NAD+ levels in healthy subjects 1.
- The study suggests that NMN administration can increase NAD+ levels in various organs and ameliorate aging-related diseases, such as obesity, diabetes, heart failure, stroke, kidney failure, and Alzheimer's disease through NAD+-mediated pathways.
- However, the study focused on oral NMN administration, and the optimal method of raising NAD levels, including subcutaneous NAD administration, requires further investigation.
Administration Technique
- Injections should be given into the fatty tissue of the abdomen, thigh, or back of the arm using a small insulin syringe (typically 29-31 gauge).
- Injection sites should be rotated to prevent tissue irritation.
- Some patients may experience mild burning or redness at the injection site, which typically resolves quickly.
Monitoring and Adjustment
- Individual response varies, so dosing may need adjustment based on symptomatic improvement and tolerance.
- Patients should be monitored for adverse effects, such as tissue irritation or other local reactions, and the dosing regimen adjusted accordingly.