From the Guidelines
The best delivery method for NAD+ injections is intravenous (IV) administration, which provides the most efficient absorption and bioavailability compared to other routes. Typical IV NAD+ protocols involve slow infusions of 500-1000mg diluted in saline solution, administered over 2-4 hours to minimize side effects like flushing and nausea. When administering NAD+ injections, it is crucial to use a sterile, single-use, disposable needle and syringe for each injection given 1. Subcutaneous injections are an alternative but less effective option, typically using 100-200mg doses. NAD+ therapy is commonly administered in a series of treatments, often 1-3 times weekly for 4-8 weeks, followed by maintenance sessions as needed. IV administration bypasses the digestive system where NAD+ would otherwise be broken down, allowing the molecule to directly enter the bloodstream and reach cells intact. This maximizes its effectiveness in supporting cellular energy production, DNA repair, and other metabolic functions. Some key considerations for the administration of NAD+ injections include:
- Ensuring proper hydration before treatment to minimize potential side effects like headaches or dizziness that some patients experience during infusions
- Supervision by qualified healthcare providers to prevent discomfort and reduce effectiveness
- Using sterile equipment for each injection to prevent infection, as emphasized in the study on infection prevention and control in pediatric ambulatory settings 1
- Considering the benefits of IV administration, as seen in the guidance on the use of bisphosphonates in solid tumours, which recommends IV administration for ensuring adherence and persistence compared with oral administration 1.
From the Research
NAD+ Injections Delivery Methods
There are various methods to deliver NAD+ injections, but the most effective method is not clearly established.
- The study 2 used intravenous nicotinamide riboside to elevate mouse skeletal muscle NAD+, which suggests that intravenous delivery may be a viable option.
- However, the study 3 used oral administration of nicotinamide riboside, which also increased whole-blood NAD+ levels, indicating that oral delivery may also be effective.
- The study 4 reviewed various clinical trials and found that oral administration of NADH and its precursors was well-tolerated and associated with improved clinical outcomes.
Comparison of Delivery Methods
The comparison of different delivery methods is limited, and more research is needed to determine the most effective method.
- The study 5 suggested that pharmacological methods to increase NAD levels should be compared to physiological means, such as exercise and dietary interventions.
- The study 6 discussed the challenges related to the bioavailability and safety of nicotinamide riboside, which may impact the choice of delivery method.
Potential Therapeutic Uses
NAD+ injections may have potential therapeutic uses for various conditions, including: