From the Research
The best delivery method for NAD+ is oral supplementation with NAD+ precursors like NMN or NR at 250-1000mg daily, as it is safe, tolerable, and can increase NAD+ abundance in multiple tissues, according to the most recent and highest quality study 1. When considering the delivery of NAD+, several factors come into play, including bioavailability, safety, and efficacy.
- Oral supplements, such as NAD+ precursors like NMN or NR, have been shown to be effective in increasing NAD+ levels in the body 2, 1.
- The typical dosing regimen for oral supplements ranges from 250-1000mg daily, with some studies suggesting that higher doses may be more effective in certain populations 3.
- Alternative delivery methods, such as intravenous (IV) infusion, sublingual tablets, nasal sprays, and transdermal patches, may also be effective, but the evidence is less clear, and these methods may have varying levels of bioavailability and safety profiles.
- It is essential to note that any NAD+ therapy should be discussed with a healthcare provider first, especially for those with existing health conditions or who are taking medications, to ensure safe and effective use.
- The body uses NAD+ as a crucial coenzyme in hundreds of metabolic processes, including energy production, DNA repair, and cellular signaling, making it a promising therapeutic target for various age-related and metabolic conditions 4, 5.