What is the treatment for buttock erythema in a neonate?

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Last updated: September 25, 2025View editorial policy

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Treatment for Buttock Erythema in a Neonate

For buttock erythema in neonates, use a barrier cream containing zinc oxide or petroleum jelly at every diaper change, keep the area clean and dry, and change diapers frequently to prevent further irritation and promote healing. 1

Assessment and Diagnosis

Before initiating treatment, assess the severity and characteristics of the buttock erythema:

  • Evaluate for signs of infection (increased redness, warmth, swelling, drainage)
  • Check if the rash extends beyond the diaper area
  • Note if there are open sores, blisters, or pustules
  • Assess for systemic symptoms such as fever

Treatment Algorithm

First-Line Treatment

  1. Diaper Care:

    • Change diapers frequently (every 2-3 hours and immediately after bowel movements)
    • Use superabsorbent disposable diapers with gelling material to keep moisture away from skin 1
    • Modify diapers by trimming the inner elastic and lining with a soft cloth coated with emollient to reduce friction 1
  2. Cleansing:

    • Gently clean the area with warm water (not cold) to reduce pain 1
    • Avoid aggressive rubbing which can worsen irritation
    • Baby wipes or water with a soft washcloth have comparable effects on diapered skin 2
  3. Barrier Protection:

    • Apply a thick layer of barrier cream containing zinc oxide or petroleum jelly at every diaper change 1
    • Zinc oxide-based creams have shown effectiveness in treating diaper dermatitis 3
  4. Air Exposure:

    • Allow diaper-free time to promote healing 1

For Moderate to Severe Cases

  1. Consider antimicrobial treatment if signs of infection are present:

    • Consult a dermatologist for planning wound management if infection is suspected 4
    • Note that antimicrobials are not recommended as first-line treatment for neonates without signs of infection 4
  2. Pain Management:

    • Monitor pain using a validated neonatal pain scale such as NIPS or FLACC 4
    • For significant discomfort, consider appropriate pain relief options such as sucrose or paracetamol/acetaminophen 4

Special Considerations

Prevention of Further Irritation

  • Use emollients on wound care products to reduce shearing when removed 4, 1
  • Secure any dressings with gauze bandages or tubular bandages instead of adhesive tape 4, 1
  • Review the area with each diaper change to respond quickly if new blisters appear 4

Monitoring for Complications

  • Monitor closely for signs of infection or sepsis, which can lead to rapid deterioration 4
  • Watch for changes in behavior and pain scores that might indicate worsening condition 4
  • Seek medical attention if the rash worsens, doesn't improve after 7 days of home treatment, or if the baby develops fever 1

Parent Education

  • Gradually increase parents' participation in skin care 4
  • Teach proper cleaning and application of barrier creams 1
  • Explain signs of infection that warrant medical attention 1

Treatment Efficacy

Research shows that barrier creams containing zinc oxide deliver more effective results than alternatives like human breast milk, particularly for moderate to severe dermatitis 5. A recent study demonstrated that zinc oxide-based barrier creams showed significant improvement in diaper dermatitis over a 30-day period 3.

Common Pitfalls to Avoid

  • Avoid using adhesive tape directly on the skin
  • Do not use aggressive rubbing when cleaning
  • Avoid salicylic acid preparations in children under 2 years of age 1
  • Do not ignore signs of infection or worsening condition
  • Avoid leaving wet or soiled diapers on for extended periods

By following this treatment approach, most cases of buttock erythema in neonates should resolve within 3-7 days. If the condition persists or worsens despite appropriate care, further medical evaluation is necessary to rule out other conditions or complications.

References

Guideline

Scar Prevention and Treatment in Children

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

A novel treatment of diaper dermatitis in children and adults.

Journal of cosmetic dermatology, 2021

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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