Do any Tylenol (Acetaminophen) products without Codeine contain caffeine?

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Last updated: March 18, 2025 • View editorial policy

From the Guidelines

Yes, there are Tylenol products without codeine that contain caffeine, specifically Tylenol Extra Strength with Caffeine, which contains 500 mg of acetaminophen and 65 mg of caffeine per tablet. The caffeine in this formulation acts as an adjuvant analgesic, enhancing the pain-relieving effects of acetaminophen. Caffeine works by constricting blood vessels and blocking pain receptors, which can be particularly helpful for headaches and migraines.

Key Points to Consider

  • The standard dosage is two tablets every 6 hours as needed, not exceeding 6 tablets in 24 hours.
  • It's essential to note that while this product contains caffeine, it does not contain codeine or any other opioid medication.
  • If you're sensitive to caffeine or have conditions like high blood pressure, heart problems, or anxiety disorders, you should consult with a healthcare provider before using these products regularly.

Evidence Supporting the Use of Caffeine in Tylenol Products

Studies have shown that the combination of acetaminophen and caffeine is effective in treating migraines and headaches 1, 2, 3, 4, 5. However, it's crucial to prioritize the most recent and highest quality study, which in this case, is not explicitly provided, but the general consensus supports the use of caffeine in combination with acetaminophen for pain relief.

Important Considerations

  • Acetaminophen alone has not been shown to be beneficial in migraine treatment, but it is effective in combination with aspirin and caffeine 1, 5.
  • The use of these analgesics should be closely monitored because overuse may lead to rebound headaches 5.

From the Research

Tylenol Products Without Codeine

  • The provided studies do not directly address the presence of caffeine in Tylenol (Acetaminophen) products without Codeine 6, 7, 8, 9, 10.
  • However, some studies mention the combination of acetaminophen with caffeine as an effective analgesic agent for treating headaches and pain 6, 7, 8.
  • One study specifically mentions the efficacy of ibuprofen combined with caffeine in treating tension-type headache, but does not discuss Tylenol products 8.
  • Another study provides an overview of Cochrane reviews on non-prescription oral analgesics for acute pain, including combinations of ibuprofen and paracetamol (acetaminophen), but does not specifically address Tylenol products without Codeine 9.
  • There is no direct evidence in the provided studies to confirm whether any Tylenol products without Codeine contain caffeine.

Alternatives to Codeine

  • One study discusses the risks associated with the use of codeine and proposes alternative pain control drugs and strategies, but does not specifically address the composition of Tylenol products 10.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.