Differential Diagnosis for Calcified Granuloma
- Single most likely diagnosis
- Healed Histoplasmosis: This is a common cause of calcified granulomas, especially in endemic areas. Histoplasmosis is a fungal infection that can lead to the formation of granulomas, which may calcify over time as the body heals.
- Other Likely diagnoses
- Tuberculosis (TB): TB can cause granulomas that calcify, especially in the lungs. While TB is a significant concern globally, the presence of calcification suggests a healed or chronic process.
- Sarcoidosis: This condition can lead to granuloma formation in various organs, including the lungs and lymph nodes. While sarcoidosis granulomas are typically non-caseating and may not always calcify, it remains a consideration in the differential diagnosis.
- Silicosis: A occupational lung disease caused by the inhalation of silica particles, leading to granuloma formation and potential calcification.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Malignancy (e.g., Lung Cancer): Although less common, calcified granulomas can be associated with certain types of malignancies. It's crucial to rule out cancer, as the treatment and prognosis are significantly different.
- Parasitic Infections (e.g., Hydatid Disease): Certain parasitic infections can cause calcified cysts or granulomas, particularly in endemic areas. Missing these diagnoses could lead to significant morbidity.
- Rare diagnoses
- Berylliosis: A rare occupational lung disease caused by exposure to beryllium, which can lead to granulomatous disease and calcification.
- Granulomatosis with Polyangiitis (Wegener's Granulomatosis): A rare autoimmune disorder that can cause granulomatous inflammation and, less commonly, calcification in various organs, including the lungs.