Diabetes Mellitus with Peripheral Artery Disease: This condition is a common cause of non-healing wounds, especially in the lower extremities, due to impaired circulation and neuropathy, which can lead to unnoticed trauma and subsequent infection.

Venous Insufficiency: Leads to chronic venous ulcers, which are difficult to heal due to the increased pressure and fluid accumulation in the affected limb.
Pressure Ulcer: Common in immobile patients, these ulcers can become chronic and bleed due to constant pressure on a specific area, impairing blood flow.
Infection: Bacterial, fungal, or viral infections can prevent a wound from healing by causing ongoing inflammation and tissue damage.
Poor Nutrition: Inadequate intake of proteins, vitamins (especially Vitamin C), and minerals (like zinc) can significantly impair the wound healing process.

Malignancy: Certain types of skin cancers (e.g., squamous cell carcinoma, basal cell carcinoma) can present as non-healing ulcers. Missing this diagnosis could lead to significant morbidity and mortality.
Vasculitis: Inflammation of the blood vessels can lead to skin ulcers that do not heal. This condition requires prompt treatment to prevent further complications.
Sickle Cell Disease: Patients with sickle cell disease can develop ulcers due to sickling crises, which can lead to tissue ischemia and necrosis.

Pyoderma Gangrenosum: A rare skin condition characterized by painful ulcers, which can be mistaken for other types of wounds or infections.
Ehlers-Danlos Syndrome: A group of disorders that affect connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues. Some types can lead to poor wound healing.
Factitious Disorder (Munchausen Syndrome): A psychiatric disorder wherein a person repeatedly acts as if they have a physical or mental illness when they are not really sick. This could include creating or exacerbating wounds.