From the FDA Drug Label
KENALOG-40 40 mg per mL 40 mg/mL, 1 mL single-dose vial 40 mg/mL, 5 mL multiple-dose vial 40 mg/mL, 10 mL multiple-dose vial
To determine the new concentration of Kenolog (Triamcinolone) after diluting 40 mg/1ml with 5 mls, we need to calculate the total amount of triamcinolone and the total volume.
- The initial concentration is 40 mg/mL.
- The initial volume is 1 mL.
- The diluent volume is 5 mL.
- The total volume after dilution is 1 mL + 5 mL = 6 mL.
- The total amount of triamcinolone is 40 mg.
- The new concentration is 40 mg / 6 mL = 6.67 mg/mL. The new concentration of Kenolog (Triamcinolone) after diluting 40 mg/1ml with 5 mls is 6.67 mg/mL 1 1.
From the Research
The new concentration of kenolog after dilution is 6.67 mg/ml. To calculate this, I started with the original concentration of 40 mg/1ml. When we add 5 ml of diluent to the original 1 ml of medication, we now have a total volume of 6 ml. The amount of active medication remains the same at 40 mg, but it's now distributed in 6 ml of solution. Dividing 40 mg by 6 ml gives us 6.67 mg/ml as the new concentration. This dilution process is commonly used to adjust medication concentration for specific administration routes or patient needs. When performing such dilutions in practice, it's essential to use appropriate sterile technique and ensure thorough mixing to achieve a uniform concentration throughout the solution, as noted in various studies 2, 3, 4, 5, 6. Some studies have discussed the use of triamcinolone acetonide in different contexts, including its efficacy in treating allergic rhinitis 6 and its ocular safety profile 4, 5, but these do not directly impact the calculation of the new concentration after dilution. The key point is to ensure that the dilution is done accurately and safely to maintain the effectiveness of the medication while minimizing potential risks. In clinical practice, understanding how to properly dilute medications like kenolog is crucial for achieving the desired therapeutic effect while ensuring patient safety, which aligns with the principles of minimizing morbidity, mortality, and maximizing quality of life.