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Last updated: September 27, 2025View editorial policy

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Differential Diagnosis for a 6-year-old with Purulent Penile Discharge and Fever

  • Single most likely diagnosis:
    • Urinary Tract Infection (UTI): This is a common condition in children that can cause symptoms such as fever and purulent discharge, especially if the infection involves the urethra.
  • Other Likely diagnoses:
    • Balanitis: An inflammation of the glans penis, which can be caused by infection, and is a common cause of penile discharge in children.
    • Phimosis: A condition where the foreskin cannot be fully retracted over the glans penis, which can lead to accumulation of smegma and potentially cause infection.
    • Urethritis: Inflammation of the urethra, which can be caused by infection and result in discharge and fever.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Testicular torsion: Although this condition typically presents with acute testicular pain, it's a surgical emergency and must be considered in the differential diagnosis of any acute scrotal or penile condition.
    • Epididymitis: Inflammation of the epididymis, which can be caused by bacterial infection and requires prompt treatment to prevent complications.
    • Sexually Transmitted Infections (STIs): Although less common in this age group, STIs such as gonorrhea or chlamydia can cause urethritis and must be considered, especially if there's a suspicion of sexual abuse.
  • Rare diagnoses:
    • Fixed drug eruption: A rare condition that can cause lesions and potentially discharge on the genital area in response to certain medications.
    • Behçet's disease: A rare form of vasculitis that can cause genital ulcers and potentially other symptoms like fever, though it's extremely uncommon in children.
    • Granuloma inguinale: A rare STI caused by Klebsiella granulomatis, which can cause ulcerative lesions on the genitals.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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