What are the red flags for diplopia (double vision)?

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Differential Diagnosis for Red Flags Double Vision

  • Single most likely diagnosis
    • Multiple Cranial Neuropathies (e.g., due to Diabetes Mellitus): This condition often presents with double vision due to the involvement of cranial nerves III, IV, or VI, which control eye movements. Diabetes is a common cause and can lead to multiple cranial neuropathies, making it a likely diagnosis for double vision with red flags.
  • Other Likely diagnoses
    • Thyroid Ophthalmopathy: This condition can cause double vision due to the involvement of extraocular muscles and nerves. It is often associated with other symptoms like exophthalmos and eyelid retraction.
    • Myasthenia Gravis: An autoimmune disorder that affects the neuromuscular junction, leading to fluctuating muscle weakness, including the muscles controlling eye movements, which can cause double vision.
    • Stroke or Transient Ischemic Attack (TIA): Although less common as a primary cause of double vision, a stroke or TIA can affect the brainstem or cranial nerves, leading to diplopia.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Aneurysm (e.g., Posterior Communicating Artery Aneurysm): An expanding aneurysm can compress cranial nerve III, leading to double vision, and is a medical emergency if it ruptures.
    • Pituitary Apoplexy: A sudden hemorrhage or infarction of a pituitary tumor can compress surrounding structures, including cranial nerves, causing double vision among other symptoms.
    • Cavernous Sinus Thrombosis: A rare but potentially life-threatening condition that can cause double vision by affecting the cranial nerves passing through the cavernous sinus.
  • Rare diagnoses
    • Wernicke's Encephalopathy: A condition caused by thiamine deficiency, often seen in alcoholics, which can lead to ophthalmoplegia and double vision.
    • Tolosa-Hunt Syndrome: A rare disorder characterized by inflammation of the cavernous sinus or superior orbital fissure, leading to painful ophthalmoplegia and double vision.
    • Gradenigo's Syndrome: A rare condition caused by inflammation of the petrous apex, leading to a triad of symptoms including double vision due to abducens nerve palsy.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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