From the Guidelines
There is no evidence to support the use of Topiramate (Topamax) in treating Burning Mouth Syndrome, and instead, gabapentin has been shown to be effective in reducing symptoms of burning in the mouth 1.
Treatment Options for Burning Mouth Syndrome
The management of burning mouth syndrome is complex and often involves a multidisciplinary approach. According to the NCCN guidelines, treatment options for oral dysesthesia, including burning mouth syndrome, include:
- Gabapentin, which has been evaluated in a randomized, double-blind, placebo-controlled trial and shown to reduce burning sensation in some patients 1
- High potency topical steroids (gel or dental paste preferred)
- Viscous lidocaine
- Dietary modifications
- Assessing the location and character of pain, ruling out odontogenic or mucosal source, and assessing the severity of pain and impact on function
Important Considerations
It is essential to note that the evidence for treating burning mouth syndrome is limited, and more research is needed to determine the most effective treatment options. Patients should always consult with healthcare providers before starting any medication regimen, as potential side effects and interactions need to be carefully considered. Alternative approaches like avoiding spicy foods, alcohol, and tobacco may also help manage symptoms.
Key Takeaways
- Gabapentin is a potential treatment option for burning mouth syndrome, with some evidence supporting its effectiveness 1
- Topiramate is not recommended for treating burning mouth syndrome due to a lack of evidence
- A multidisciplinary approach, including dietary modifications and topical measures, may be necessary to manage symptoms effectively
From the Research
Efficacy of Topiramate in Treating Burning Mouth Syndrome
- There are limited studies directly investigating the efficacy of Topiramate (Topamax) in treating Burning Mouth Syndrome.
- However, a study published in 2007 2 reported a case of a 65-year-old woman with glossodynia, which is characterized by painful sensations in the mouth and throat, and is sometimes associated with Burning Mouth Syndrome.
- In this case, treatment with topiramate induced a complete improvement of symptoms, suggesting that topiramate could be a useful therapeutic option in the treatment of glossodynia and potentially Burning Mouth Syndrome.
- Another study published in 2003 3 reviewed the use of topiramate for treating neuropathic pain, which may be related to Burning Mouth Syndrome, and suggested that topiramate may be effective in alleviating neuropathic pain due to its multiple mechanisms of action.
- A 2013 systematic review 4 found no convincing evidence for the efficacy of topiramate in treating neuropathic pain, but this review focused on diabetic neuropathic pain and may not be directly applicable to Burning Mouth Syndrome.
- Other studies have investigated the use of gabapentin for treating Burning Mouth Syndrome 5, but the efficacy of topiramate specifically for this condition remains largely unexplored.