How is Plan B (levonorgestrel) taken?

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How to Take Plan B (Levonorgestrel)

Plan B should be taken as a single 1.5 mg tablet as soon as possible within 72 hours (3 days) after unprotected intercourse or contraceptive failure, with earlier administration providing better effectiveness. 1

Administration Details

  • Plan B (levonorgestrel) is available as:

    • A single 1.5 mg tablet (Plan B One-Step)
    • Two 0.75 mg tablets (generic versions) that can be taken together as a single dose 2, 1
  • No prescription is required:

    • Plan B One-Step is FDA-approved as a nonprescription product for all women of childbearing potential
    • Generic versions are approved as nonprescription for women 17 years and older (though proof of age is not required to purchase) 2

Timing and Effectiveness

  • Timing is critical: The sooner Plan B is taken after unprotected sex, the more effective it is 1
  • While most effective within 72 hours, it can be taken up to 5 days (120 hours) after unprotected intercourse 2, 3
  • Effectiveness:
    • Prevents approximately 75-80% of expected pregnancies when taken correctly 3
    • About 7 out of 8 women who would have gotten pregnant will not become pregnant 1

What to Do If Vomiting Occurs

  • If vomiting occurs within 2 hours of taking Plan B, contact a healthcare professional to determine if the dose should be repeated 1

Special Considerations

  • Weight considerations: Plan B may lose effectiveness in women who weigh more than 165 pounds and may be ineffective in women who weigh more than 176 pounds 2
  • Medication interactions: Effectiveness may be reduced if taking:
    • Efavirenz (HIV medication)
    • Rifampin (tuberculosis treatment)
    • Medications for seizures/epilepsy 1

Common Side Effects

  • Changes in menstrual cycle (heavier/lighter or early/late period)
  • Nausea
  • Lower abdominal pain
  • Tiredness
  • Headache
  • Dizziness
  • Breast tenderness 1

Important Warnings

  • Plan B will not work if you are already pregnant and will not affect an existing pregnancy
  • It will not protect against HIV/AIDS or other sexually transmitted diseases
  • It should not be used as a regular form of birth control as it is less effective than other contraceptive methods 1, 3
  • Seek immediate medical attention if experiencing severe abdominal pain, as this could indicate an ectopic pregnancy 1

How to Know If It Worked

You will know Plan B has been effective when you get your next period, which should come at the expected time or within a week of the expected time. If your period is delayed more than a week, take a pregnancy test and follow up with your healthcare provider 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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