Should monkeypox be managed with contact or respiratory precautions?

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Last updated: October 2, 2025View editorial policy

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Monkeypox Infection Control: Contact and Respiratory Precautions

Monkeypox requires both contact and respiratory precautions due to its transmission through direct contact with lesions, contaminated materials, and respiratory droplets. 1

Transmission Routes of Monkeypox

Monkeypox virus can be transmitted through multiple routes:

  • Direct contact with skin lesions or body fluids 1, 2
  • Respiratory droplets during close, prolonged face-to-face contact 2
  • Fomites (contaminated objects) such as bedding, towels, and clothing 1, 2
  • Contact with contaminated materials from lesions 3

Required Infection Control Measures

Contact Precautions

Contact precautions are essential due to the high likelihood of transmission through direct or indirect contact with the patient or their environment 4:

  • Single-patient room or >3 ft spatial separation from other patients
  • Appropriate PPE including gloves and gown
  • Proper donning upon entry and discarding before exiting
  • Limited transport and movement of patient
  • Dedicated or disposable patient-care equipment
  • Prioritized cleaning and disinfection of the room 4

Respiratory Precautions

Because monkeypox can also spread through respiratory droplets, droplet precautions are necessary 4, 2:

  • Single-patient room or >3 ft spatial separation
  • Appropriate mask use upon entry to patient room
  • Source control: placing a mask on the patient
  • Instructing patient in respiratory hygiene/cough etiquette
  • Limited transport and movement of patient 4

Isolation Requirements

  • Isolation until all lesions have crusted over 1
  • Proper handling of contaminated materials:
    • Place used bandages in sealed plastic bags before disposal 1
    • Launder contaminated clothing, towels, and bedding in hot water with bleach 4

Special Considerations

Healthcare Worker Protection

  • Healthcare workers should keep vaccination sites covered with gauze or absorbent material with a semipermeable dressing 4
  • Meticulous hand hygiene with antimicrobial soap and water or alcohol-based hand rub (>60% alcohol) is critical 4, 1
  • Daily assessment of dressings and vaccination sites 4

Documented Transmission Risk

A documented case of monkeypox transmission from a patient to a healthcare worker in the UK occurred through contact with contaminated bedding, highlighting the importance of proper contact precautions 3.

Common Pitfalls to Avoid

  1. Inadequate hand hygiene: The most critical measure in preventing transmission is consistent hand hygiene after any contact with lesions or contaminated materials 4, 1

  2. Improper handling of contaminated materials: Contaminated bandages should be placed in sealed plastic bags before disposal 1

  3. Premature discontinuation of precautions: Isolation should continue until all lesions have crusted over, not just until symptoms improve 1

  4. Focusing only on contact precautions: Both contact and respiratory precautions are necessary due to the multiple transmission routes 4, 2

By implementing both contact and respiratory precautions, healthcare facilities can effectively minimize the risk of monkeypox transmission to healthcare workers and other patients.

References

Guideline

Monkeypox Treatment Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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