Chymoral Forte Tablet Dosing for Adults
For adults, the recommended dosage of Chymoral Forte (trypsin-chymotrypsin) tablets is 2 tablets every 2 hours until relief is achieved. 1
Administration Guidelines
The proper administration of Chymoral Forte tablets is crucial for optimal efficacy:
- Take the medication sublingually (under the tongue)
- Place tablets under the tongue at least 15 minutes before eating or 30 minutes after eating, brushing teeth, or drinking anything except water
- Allow the tablet to dissolve completely under the tongue for proper absorption
- Maintain consistent timing between doses (every 2 hours) until symptoms improve
Clinical Evidence and Mechanism of Action
Chymoral Forte contains a combination of trypsin and chymotrypsin enzymes that have demonstrated anti-inflammatory properties. Research has shown that this enzyme combination works by:
- Modulating cytokine levels, particularly IL-6 and IL-1beta, which helps regulate inflammatory responses 2
- Affecting acute-phase proteins following injury, which reflects its anti-inflammatory activity 3
- Enhancing the rise in alpha 1-antitrypsin, alpha 2-macroglobulin, and trypsin inhibitory capacity (TIC) while inhibiting C-reactive protein 3
Treatment Duration
The optimal duration of treatment with Chymoral Forte depends on the condition being treated and the patient's response:
- For acute inflammatory conditions: Continue treatment every 2 hours until relief is achieved
- For post-surgical inflammation: Treatment may be required for several days
- For chronic conditions: Duration should be based on symptom improvement
Precautions and Contraindications
When prescribing Chymoral Forte, be aware of these important considerations:
- Not recommended for children under 6 years without physician consultation
- Use with caution in patients with bleeding disorders as proteolytic enzymes may theoretically affect blood coagulation
- Monitor patients with a history of gastrointestinal ulcers as proteolytic enzymes could potentially exacerbate these conditions
Common Pitfalls to Avoid
- Inadequate sublingual administration: Ensure patients understand the importance of proper sublingual placement rather than swallowing the tablets
- Inconsistent dosing: Emphasize the importance of maintaining the every-2-hour schedule until relief is achieved
- Premature discontinuation: Advise patients to complete the recommended course even if symptoms begin to improve
While some studies have shown limited efficacy in certain conditions like lumbar disc prolapse 4, Chymoral Forte has demonstrated more promising results in managing acute inflammatory conditions, particularly in burn patients 2, 3 and acute hemorrhoids 5.