Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 2, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Pain, Redness, and Swelling in the Left Breast of a 58-Year-Old

Single Most Likely Diagnosis

  • Mastitis: This is an inflammation of the breast tissue, which can be infectious or non-infectious. Given the symptoms of pain, redness, and swelling, mastitis is a common and likely diagnosis, especially if the patient has a history of recent trauma, surgery, or infection in the breast.

Other Likely Diagnoses

  • Breast Abscess: A collection of pus in the breast tissue, often as a complication of mastitis. It presents with similar symptoms and is a consideration, especially if there's a fluctuant mass or significant tenderness.
  • Fat Necrosis: A condition where the breast fat tissue dies, often due to trauma. It can mimic signs of infection or malignancy, including pain, swelling, and sometimes skin retraction.
  • Periductal Mastitis: Inflammation of the ducts under the nipple, leading to symptoms like pain, swelling, and sometimes nipple retraction or discharge.

Do Not Miss Diagnoses

  • Inflammatory Breast Cancer (IBC): A rare but aggressive form of breast cancer that presents with rapid onset of swelling, redness, and warmth of the breast, often without a distinct lump. It's crucial to consider IBC due to its poor prognosis if not promptly treated.
  • Necrotizing Fasciitis: A severe infection of the skin and underlying tissue, which can rapidly progress and is life-threatening. While rare, its severity warrants consideration in cases of severe pain, swelling, and redness.

Rare Diagnoses

  • Granulomatous Mastitis: A rare inflammatory condition of the breast characterized by granulomatous inflammation. It can mimic other conditions, including breast cancer, and is often diagnosed after biopsy.
  • Sarcoidosis of the Breast: A rare condition where granulomatous inflammation affects the breast tissue. It's part of systemic sarcoidosis and can present with a variety of symptoms, including pain and swelling.
  • Breast Lymphoma: A rare malignancy that can present with swelling, pain, and sometimes systemic symptoms. It's essential to consider in the differential, especially if other diagnoses are ruled out.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.