How long is a child with hand, foot, and mouth disease (HFMD) contagious and when is it safe for them to return to school?

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Last updated: October 3, 2025View editorial policy

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Hand, Foot, and Mouth Disease: Contagious Period and Return to School Guidelines

Children with hand, foot, and mouth disease (HFMD) are typically contagious from 1-2 days before symptoms appear until all blisters have dried and crusted over, usually 7-10 days from symptom onset, and should not return to school until they are no longer contagious.

Understanding HFMD Transmission

HFMD is a highly contagious viral illness primarily caused by enteroviruses, particularly:

  • Coxsackievirus A16 (CV-A16)
  • Enterovirus 71 (EV-A71)
  • Coxsackievirus A6 (CV-A6)
  • Coxsackievirus A10 (CV-A10) 1, 2

The virus spreads through multiple routes:

  • Direct contact with respiratory secretions, saliva, or fluid from blisters 3
  • Fecal-oral transmission 1
  • Contact with contaminated surfaces and objects (fomites) 1

Contagious Period

The contagious period for HFMD follows a specific timeline:

  • Begins 1-2 days before symptoms appear 3
  • Continues throughout the acute illness phase 1
  • Extends until all blisters have dried and crusted over 1
  • Generally lasts 7-10 days from symptom onset 1, 3

However, it's important to note that:

  • Viral shedding can continue in stool for several weeks after symptoms resolve 3
  • Some studies suggest patients should be considered potentially contagious for at least 10-14 days 3

When to Return to School

Children with HFMD should not return to school until:

  • Fever has resolved without fever-reducing medications 3
  • All blisters/vesicles have dried and crusted over 1
  • At least 7 days have passed since symptom onset 3

Preventing Transmission

To prevent spreading HFMD to others:

  • Practice thorough handwashing with soap and water (alcohol-based sanitizers alone are not sufficient) 3
  • Avoid close contact with others during the contagious period 3
  • Use separate towels and utensils 3
  • Disinfect frequently touched surfaces and toys 1
  • Properly dispose of tissues containing nasal secretions 3

Special Considerations

High-Risk Settings

Those in professions with high potential for transmission should be especially cautious:

  • Healthcare workers should follow strict infection control protocols 3
  • Childcare providers should be particularly vigilant about handwashing and disinfection 3

Complications

While HFMD is typically self-limiting, parents should be aware of potential complications:

  • Rare neurological complications like meningitis or encephalitis 1, 4
  • Dehydration from painful oral ulcers limiting fluid intake 1
  • Secondary bacterial infections of skin lesions 1

Treatment

Treatment is supportive and focuses on:

  • Maintaining adequate hydration 1
  • Pain relief with acetaminophen or ibuprofen as needed 1
  • Avoiding spicy, acidic, or hot foods that may irritate mouth ulcers 5

Common Pitfalls to Avoid

  1. Returning to school too early: Children who return before the contagious period ends can trigger outbreaks 3

  2. Relying only on fever resolution: Some parents may send children back to school once fever resolves, but the child remains contagious until all lesions have crusted 3

  3. Inadequate hand hygiene: Using only alcohol-based sanitizers is insufficient; soap and water are more effective against enteroviruses 3

  4. Overlooking environmental cleaning: Enteroviruses can remain viable on surfaces for up to 28 days 3

  5. Assuming mild cases aren't contagious: Even mild cases with few lesions can transmit the virus effectively 6

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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