What is the cause of my arm and shoulder symptoms?

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Last updated: March 21, 2025View editorial policy

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Differential Diagnosis for Arm and Shoulder Complaints

The following differential diagnosis is organized into categories to help guide the thought process.

  • Single Most Likely Diagnosis
    • Musculoskeletal Strain or Sprain: This is often the most common cause of arm and shoulder pain, typically resulting from overuse, injury, or poor posture. Justification: High prevalence, common presentation, and often related to recent activity or trauma.
  • Other Likely Diagnoses
    • Tendinitis or Bursitis: Inflammation of the tendons or bursae around the shoulder joint can cause significant pain and limited mobility. Justification: Common conditions, especially in individuals who perform repetitive motions or have jobs involving heavy lifting.
    • Cervical Radiculopathy: Nerve root compression in the cervical spine can radiate pain to the arms and shoulders. Justification: A frequent cause of arm pain, especially when accompanied by neck pain or stiffness.
    • Thoracic Outlet Syndrome: Compression of the nerves or blood vessels between the collarbone and first rib can lead to arm and shoulder pain. Justification: Considered when there's a history of trauma, poor posture, or anatomical abnormalities.
  • Do Not Miss Diagnoses
    • Myocardial Infarction: Although less common, arm pain can be a presenting symptom of a heart attack, especially if the pain is radiating or accompanied by other cardiac symptoms. Justification: Critical to diagnose promptly due to the high risk of mortality.
    • Pulmonary Embolism: In rare cases, arm pain can be associated with a pulmonary embolism, particularly if there's a history of deep vein thrombosis or recent immobilization. Justification: Potentially life-threatening, thus important not to miss.
    • Spinal Cord Injury or Compression: Acute trauma or progressive conditions like spinal stenosis can cause arm and shoulder pain due to spinal cord compression. Justification: Urgent diagnosis and treatment are necessary to prevent permanent neurological damage.
  • Rare Diagnoses
    • Polymyalgia Rheumatica: An inflammatory condition that causes muscle pain and stiffness, often in the shoulders and arms. Justification: Less common, but important to consider in older adults with systemic symptoms like fever and weight loss.
    • Complex Regional Pain Syndrome: A chronic pain condition characterized by severe, burning pain in the arms or shoulders, often following an injury. Justification: Rare, but significant due to its impact on quality of life and the challenge of treatment.
    • Neoplastic Conditions: Tumors affecting the nerves, bones, or soft tissues in the arm or shoulder region can cause pain. Justification: Although rare, neoplastic conditions are critical to diagnose early for effective treatment and prognosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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