What is the management protocol for cardiac arrest?

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Last updated: October 4, 2025View editorial policy

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Cardiac Arrest Management Protocol

The management of cardiac arrest requires a structured approach following the chain of survival, which includes prompt recognition, early CPR, rapid defibrillation, effective advanced life support, and integrated post-arrest care to optimize outcomes. 1

Immediate Response and Recognition

  • Cardiac arrest should be assumed in any collapsed and unresponsive individual 2
  • Seizure-like activity and abnormal breathing or gasping must be considered as signs of cardiac arrest until proven otherwise 2
  • Immediately activate the emergency medical response system and call for additional assistance 2

High-Quality CPR

  • Begin hands-only (compression-only) CPR immediately if the patient is unresponsive and not breathing normally 2
  • Push hard (at least 5 cm/2 inches deep) and fast (100-120 compressions/minute), allowing complete chest recoil 2
  • Minimize interruptions in chest compressions to maintain perfusion 2
  • Switch compressors every 2 minutes or sooner if fatigued to maintain effective compressions 2
  • For patients without advanced airway, use a 30:2 compression-to-ventilation ratio 2
  • Avoid excessive ventilation as it can impede venous return and decrease cardiac output 2

Defibrillation

  • Apply an automated external defibrillator (AED) or manual defibrillator as soon as possible while CPR continues 2
  • Stop CPR only for rhythm analysis and shock delivery if indicated 2
  • Resume CPR immediately after shock delivery for 2 minutes before reassessing rhythm 2
  • If no shock is delivered, continue CPR and life support measures until the patient becomes responsive or a non-cardiac etiology is established 2

Advanced Airway Management

  • Establish an advanced airway (endotracheal intubation or supraglottic airway device) 2
  • Confirm correct placement using waveform capnography 2
  • After advanced airway placement, provide 1 breath every 6 seconds (10 breaths/min) with continuous chest compressions 2
  • Monitor PETCO2 (typically 35-40 mm Hg) to assess CPR quality and detect return of spontaneous circulation 2

Medication Administration

  • For shock-refractory ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT), consider either amiodarone or lidocaine 2
  • Amiodarone IV/IO dose: First dose 300 mg bolus, second dose 150 mg 2
  • Lidocaine IV/IO dose: First dose 1-1.5 mg/kg, second dose 0.5-0.75 mg/kg 2
  • Consider vasopressors according to standard ACLS protocols 2

Identify and Treat Reversible Causes

  • Search for and treat the "H's and T's" of cardiac arrest 2:
    • Hypovolemia, hypoxia, hydrogen ion (acidosis), hypo/hyperkalemia, hypothermia
    • Tension pneumothorax, tamponade (cardiac), toxins, thrombosis (coronary or pulmonary)

Return of Spontaneous Circulation (ROSC) Indicators

  • Presence of pulse and blood pressure 2
  • Abrupt sustained increase in PETCO2 (typically >40 mm Hg) 2
  • Spontaneous arterial pressure waves with intra-arterial monitoring 2

Post-Cardiac Arrest Care

  • Optimize cardiopulmonary function and vital organ perfusion 2
  • Transport to an appropriate hospital with comprehensive post-cardiac arrest care capabilities 2
  • Control body temperature to optimize survival and neurological recovery 2
  • Consider therapeutic hypothermia (32-34°C) for comatose survivors 2
  • Identify and treat acute coronary syndromes 2
  • Optimize mechanical ventilation to minimize lung injury 2
  • Elevate head of bed 30° if tolerated to reduce cerebral edema, aspiration, and ventilator-associated pneumonia 2
  • Titrate inspired oxygen to achieve arterial oxygen saturation of 94% to avoid potential oxygen toxicity 2
  • Target ventilation to achieve PETCO2 of 35-40 mm Hg or PaCO2 of 40-45 mm Hg 2

Team Approach and Quality Improvement

  • Implement performance-focused debriefing for resuscitation team members after in-hospital cardiac arrest 2
  • Develop system-wide plans for proactive treatment of cardiac arrest patients 2
  • Consider transport to specialized centers with higher cardiac arrest case volumes for improved outcomes 2

Special Considerations

  • For cardiac arrest on a sports field, perform initial CPR and defibrillation at the location of collapse 2
  • Only transfer the patient after careful consideration, as external chest compression during transit may be less effective 2
  • For hypothermic patients, continue CPR until rewarming is achieved 1

By following this structured protocol for cardiac arrest management, healthcare providers can optimize the chances of successful resuscitation and improve patient outcomes.

References

Guideline

Cardiac Arrest Management Strategies

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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