From the Guidelines
Aminohydroxamic acid is not mentioned in the provided evidence, however, ε-Aminocaproic acid, an antifibrinolytic, has similar properties and is mentioned, with potential side effects including nausea, vertigo, diarrhea, postural hypotension, fatigue, and muscle cramps with increased muscle enzymes, as well as a risk of enhanced thrombosis 1.
Side Effects of Aminohydroxamic Acid
Since aminohydroxamic acid is not directly mentioned, we can consider the properties of similar compounds like ε-Aminocaproic acid, which is an antifibrinolytic. The side effects of ε-Aminocaproic acid include:
- Nausea
- Vertigo
- Diarrhea
- Postural hypotension
- Fatigue
- Muscle cramps with increased muscle enzymes
Considerations for Use
It's essential to note that while aminohydroxamic acid itself is not discussed, the provided evidence focuses on treatments for hereditary angioedema and other conditions, where antifibrinolytics like ε-Aminocaproic acid and tranexamic acid are used.
Clinical Implications
Given the information available, patients should be cautious and monitor for signs of thrombosis, as well as other side effects, when taking medications like ε-Aminocaproic acid 1. However, without direct evidence on aminohydroxamic acid, these considerations are based on the properties of similar antifibrinolytic agents.
From the Research
Side Effects of Aminohydroxyamic Acid (Tranexamic Acid)
- The studies provided do not directly mention "aminohydroxyamic acid" but rather "tranexamic acid", which is likely the intended subject of inquiry.
- Based on the available evidence, the side effects of tranexamic acid include:
- Thrombotic events:
- A study published in 2013 2 found that tranexamic acid may expose patients to a risk of thrombosis, with a 3-fold higher risk of developing deep vein thrombosis.
- However, a 2021 systematic review and meta-analysis 3 found no evidence that tranexamic acid increased the risk of thrombotic events.
- Another 2021 systematic review and meta-analysis 4 also found no association between tranexamic acid and the risk of thromboembolic events.
- Seizures:
- The 2021 systematic review and meta-analysis 3 found that high doses of tranexamic acid (more than 2 g/day) may increase the risk of seizures.
- Vascular occlusive events:
- The 2021 systematic review and meta-analysis 4 found no association between tranexamic acid and the risk of vascular occlusive events, including pulmonary embolism, deep vein thrombosis, stroke, and myocardial infarction.
- Mortality:
- The 2021 systematic review and meta-analysis 4 found that tranexamic acid was associated with a significant reduction in overall mortality and bleeding mortality.
- Thrombotic events:
- It is essential to note that the evidence on the side effects of tranexamic acid is not entirely consistent, and further research may be necessary to fully understand its effects.