Chronic Obstructive Pulmonary Disease (COPD): Given the age and potential for smoking or exposure to lung irritants, COPD is a common cause of SOB in adults. African Americans may have a higher risk due to socioeconomic factors and exposure to environmental pollutants.

Asthma: A common condition that can cause SOB, especially if the patient has allergies or is exposed to asthma triggers.
Heart Failure: As people age, the risk of heart failure increases, and it is a significant cause of SOB. African Americans are at higher risk for heart failure due to a higher prevalence of hypertension and diabetes.
Pneumonia: An infection that can cause SOB, especially in adults with underlying health conditions.
Pulmonary Embolism: Although less common, it is a significant cause of SOB and can be deadly if not treated promptly.

Pulmonary Hypertension: A condition that can lead to right heart failure and has a high mortality rate if not diagnosed and treated.
Cardiac Tamponade: A life-threatening condition where fluid accumulates in the sac around the heart, compressing it and impeding its function.
Sickle Cell Crisis: Given the patient's African American background, sickle cell disease is a possibility, and a crisis can cause SOB among other symptoms.
Acute Coronary Syndrome: Myocardial infarction (heart attack) can present with SOB, especially in women, who may not always exhibit typical chest pain symptoms.

Lymphangioleiomyomatosis (LAM): A rare lung disease that primarily affects women, causing SOB and other respiratory symptoms.
Eosinophilic Granuloma with Polyangiitis (Churg-Strauss Syndrome): A rare autoimmune condition that can cause SOB, among other systemic symptoms.
Idiopathic Pulmonary Fibrosis: A condition characterized by scarring of the lungs, leading to SOB, which is more common in older adults but can occur at any age.
Cystic Fibrosis: Although typically diagnosed in childhood, some cases may not be diagnosed until adulthood, especially in individuals with milder forms of the disease.