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Differential Diagnosis for Enlarged Testicle

The following differential diagnosis is organized into categories to help guide the thought process:

  • Single Most Likely Diagnosis
    • Hydrocele: A fluid-filled sac surrounding the testicle, which is a common cause of testicular enlargement. It is usually painless and can be diagnosed with ultrasound.
  • Other Likely Diagnoses
    • Epididymitis: Inflammation of the epididymis, often caused by bacterial infection, which can lead to testicular swelling and pain.
    • Orchitis: Inflammation of the testicle itself, often caused by viral or bacterial infection, which can cause pain, swelling, and enlargement of the testicle.
    • Varicocele: An enlargement of the veins within the scrotum, similar to varicose veins, which can cause testicular swelling and discomfort.
  • Do Not Miss Diagnoses
    • Testicular Torsion: A medical emergency where the spermatic cord becomes twisted, cutting off blood supply to the testicle. It requires immediate attention to save the testicle.
    • Testicular Cancer: Although less common, testicular cancer can present with a painless testicular enlargement. Early detection is crucial for effective treatment.
  • Rare Diagnoses
    • Spermatocele: A cystic structure filled with sperm, which can cause a painless lump on the testicle.
    • Cystic dysplasia of the testis: A rare congenital condition where the testis is replaced by multiple cysts, leading to testicular enlargement.
    • Filariasis: In areas where filariasis is endemic, it can cause testicular swelling due to parasitic infection.

Each diagnosis has a brief justification based on common causes and clinical presentations of an enlarged testicle. The categorization helps prioritize the most likely and critical diagnoses.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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