What is the appropriate dose of polyethylene glycol (PEG) for a 7-year-old female?

Polyethylene Glycol Dosing for a 7-Year-Old Female

For a 7-year-old female with constipation, the recommended dose of polyethylene glycol (PEG) is 0.7-0.8 g/kg/day, which typically equates to approximately 17-20 g daily for most children this age. 1, 2

Dosing Guidelines

• PEG 3350 is an osmotic laxative that works by drawing water into the intestine to increase stool bulk and facilitate passage 3
• For children under 17 years of age, the FDA recommends consulting a doctor for appropriate dosing 4
• Research shows that the effective maintenance dose for children is approximately 0.78 g/kg/day (range 0.26-1.26 g/kg/day) 1
• For a typical 7-year-old female weighing approximately 22-25 kg, this would translate to about 17-20 g daily 1, 2
• The powder should be fully dissolved in 4-8 ounces of beverage (cold, hot, or room temperature) before drinking 4

Administration Guidelines

• PEG should be mixed thoroughly until completely dissolved - do not drink if there are any clumps 4
• Do not combine with starch-based thickeners used for difficult swallowing 4
• Initial treatment may require a slightly higher dose (around 1 g/kg/day) with adjustment to a maintenance dose based on response 2
• Dose can be titrated based on symptom response and side effects 3
• PEG has been shown to be effective and safe for long-term use in children 2, 5

Monitoring and Adjustments

• The goal of therapy should be 1-2 soft, painless stools per day 2
• If diarrhea occurs, the dose should be reduced 1, 2
• If constipation persists, the dose can be gradually increased while monitoring for side effects 3
• PEG has no clear maximum dose, but adjustments should be made based on clinical response 3

Safety Considerations

• PEG has been shown to be safe and effective in children as young as 1 month of age 1, 2
• Common side effects include bloating, abdominal discomfort, and cramping 3
• Transient diarrhea may occur but typically resolves with dose adjustment 1, 2
• Ensure adequate hydration while using PEG 3
• Studies show a success rate of over 90% for treating constipation in children with minimal adverse effects 6, 2

Duration of Treatment

• For functional constipation, PEG may be used for extended periods with good safety profile 2, 5
• Response to PEG has been shown to be durable over 6 months or longer 3
• Treatment duration should be based on clinical response and resolution of symptoms 2, 5