From the Guidelines
Low-dose aspirin (acetylsalicylic acid) can cause fluid retention, particularly in individuals with certain heart, kidney, or liver conditions, due to its effects on renal prostaglandins and potential nephrotoxicity at high doses 1. When considering the use of low-dose aspirin, it is essential to weigh the benefits of its antiplatelet effects against the potential risks, including fluid retention.
- The risk of fluid retention is higher when aspirin is combined with other nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics 1.
- Aspirin's effects on renal prostaglandins can lead to nephrotoxicity, particularly at high doses, which can exacerbate heart failure 1.
- However, for most people, low-dose aspirin (typically 75 mg) is not associated with significant fluid retention, and its use is generally safe in the context of secondary prevention of ischemic heart disease.
- It is crucial for individuals taking low-dose aspirin to monitor for signs of fluid retention, such as swelling in the ankles, feet, hands, or face, and to consult their healthcare provider promptly if they experience any adverse reactions, especially if they have underlying heart failure or kidney disease 1.
From the Research
Low-Dose Aspirin and Fluid Retention
- The relationship between low-dose aspirin and fluid retention is not directly addressed in most of the provided studies 2, 3, 4, 5.
- However, one study 6 investigated the effect of mini-dose aspirin on renal function and uric acid handling in elderly patients, which may be related to fluid retention.
- The study found that mini-dose aspirin caused a significant decrease in the rate of uric acid excretion and a slight increase in serum levels of uric acid, which may be indicative of fluid retention 6.
- Another study 3 found that the combination of low-dose aspirin and diuretics was associated with significantly lower creatinine clearance levels, which may also be related to fluid retention.
- A study on the prediction of hyperuricemia in people taking low-dose aspirin found that the estimated glomerular filtration rate, body mass index, and waist circumference were important features for hyperuricemia in individuals taking aspirin 4.
- The study on aspirin use to prevent preeclampsia did not mention fluid retention as a potential side effect of low-dose aspirin 2.
- The study on the old drug, new uses and challenges of aspirin discussed the gastrointestinal and cardiovascular effects of aspirin, but did not mention fluid retention 5.
Key Findings
- Low-dose aspirin may cause changes in renal function and uric acid handling, which could be related to fluid retention 6.
- The combination of low-dose aspirin and diuretics may be associated with lower creatinine clearance levels, potentially indicating fluid retention 3.
- Hyperuricemia, which may be related to fluid retention, can be predicted in people taking low-dose aspirin using machine learning algorithms 4.